Skip to main content

Table 3 Unadjusted yearly change in fat free mass index (FFMI) and fat mass index (FMI) for the four infalammatory markers, estimated by linear mixed models

From: TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

  Yearly change in FFMI p-value Yearly change in FMI p-value
CRP     
  at CRP = 2.4 −0.0732   −0.0195  
  per 1 ug/mL increase 0.0121 0.10 −0.0041 0.63
Sustained high CRP at year 0 and 1     
  No −0.0828   0.0037  
  Yes 0.0320 0.046 −0.1421 0.02
TNF-α     
  at TNF-α = 1.8 −0.0597   −0.0236  
  per 1 pg/mL increase −0.0107 0.09 0.0020 0.77
Sustained high TNF-α at year 0 and 1     
  No −0.0488   −0.0283  
  Yes −0.1621 0.07 0.0366 0.36
IL-1ß     
  at IL-1ß = 0.93 −0.0611   −0.0234  
  per 1 pg/mL increase 0.0144 0.16 −0.0026 0.82
Sustained high IL-1ß at year 0 and 1     
  No −0.0723   −0.0216  
  Yes −0.0167 0.36 −0.0083 0.85
IL-6     
  at IL-6 = 2.8 −0.0613   −0.0234  
  per 1 pg/mL increase 0.0023 0.10 −0.0003 0.87
Sustained high IL-6 at year 0 and 1     
  No −0.0700   −0.0150  
  Yes −0.0251 0.49 −0.0558 0.58