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Table 3 Unadjusted yearly change in fat free mass index (FFMI) and fat mass index (FMI) for the four infalammatory markers, estimated by linear mixed models

From: TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

 

Yearly change in FFMI

p-value

Yearly change in FMI

p-value

CRP

    

  at CRP = 2.4

−0.0732

 

−0.0195

 

  per 1 ug/mL increase

0.0121

0.10

−0.0041

0.63

Sustained high CRP at year 0 and 1

    

  No

−0.0828

 

0.0037

 

  Yes

0.0320

0.046

−0.1421

0.02

TNF-α

    

  at TNF-α = 1.8

−0.0597

 

−0.0236

 

  per 1 pg/mL increase

−0.0107

0.09

0.0020

0.77

Sustained high TNF-α at year 0 and 1

    

  No

−0.0488

 

−0.0283

 

  Yes

−0.1621

0.07

0.0366

0.36

IL-1ß

    

  at IL-1ß = 0.93

−0.0611

 

−0.0234

 

  per 1 pg/mL increase

0.0144

0.16

−0.0026

0.82

Sustained high IL-1ß at year 0 and 1

    

  No

−0.0723

 

−0.0216

 

  Yes

−0.0167

0.36

−0.0083

0.85

IL-6

    

  at IL-6 = 2.8

−0.0613

 

−0.0234

 

  per 1 pg/mL increase

0.0023

0.10

−0.0003

0.87

Sustained high IL-6 at year 0 and 1

    

  No

−0.0700

 

−0.0150

 

  Yes

−0.0251

0.49

−0.0558

0.58