Figure 4

Graph of increases in moving weekly averages for the different symptom scores from the diaries at each day during follow-up. Triangles represent individual values of the increase at the day of a patient’s (first) exacerbation. The gray area represents the reference range at each day of follow-up, i.e. mean +/− 2 SD values of the increase for those who did not have an exacerbation at the days indicated.