Table 1 Cytokine concentration (pg/ml) in cell culture supernatant following in vitro K. pneumoniae infection of Alveolar Macrophages
From: Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice
Vehicle-Exposed AM | IL-6 | IP-10 | KC | LIX | MCP-1 | MIP-1a | MIP-1b | MIP-2 | TNFa |
|---|---|---|---|---|---|---|---|---|---|
PBS | 5.54 (4.54) | 43.96 (2.44) | 166.47 (11.12) | 79.93 (15.99) | 61.07 (5.78) | 68.53 (4.30) | 26.05 (8.24) | 1,225.18 (36.94) | 52.07 (0.93) |
Klebseilla | 2,506.37 (167.12) | 122.53 (5.10) | 13,917.04 (198.04) | 1,518.32 (57.78) | 68.74 (2.19) | 10,038.19 (180.37) | 9,318.00 (1,764.90) | 41,802.27 (6,019.32) | 2,012.61 (724.25) |
Klebs + 10 nm FP | 661.80* (36.50) | 125.74 (3.51) | 8,254.84* (268.01) | 931.97* (21.59) | 47.11* (1.71) | 7,731.08* (161.64) | 3,795.81* (200.74) | 11,881.55* (622.15) | 1,141.86 (100.01) |
Klebs + 100 nm FP | 472.29*# (23.18) | 116.16 (6.96) | 7,912.98* (271.24) | 818.89* (22.82) | 35.31*# (1.13) | 6,674.62*# (252.86) | 3,252.32*# (82.53) | 11,441.20 (736.01) | 1,101.10 (62.84) |
FP-Exposed AM | |||||||||
PBS | 1.00 (0) | 8.99 (1.23) | 84.31 (1.72) | 2.59 (1.59) | 43.29 (5.49) | 34.76 (2.98) | 3.54 (2.54) | 520.03 (26.90) | 19.73 (0.85) |
Klebseilla | 828.87 (85.73) | 122.38 (10.04) | 9,891.14 (525.77) | 1,056.19 (55.29) | 50.38 (2.22) | 9,111.51 (146.05) | 5,640.23 (776.27) | 14,296.83 (700.94) | 1,096.82 (115.99) |
Klebs + 10 nm FP | 354.74* (23.31) | 105.06 (5.47) | 7,472.76* (459.38) | 746.89* (45.01) | 33.22* (1.35) | 6,636.20* (378.28) | 3,670.30* (228.33) | 10,762.57* (557.97) | 1,066.93 (71.74) |
Klebs + 100 nm FP | 327.28* (27.06) | 107.73 (5.09) | 6,492.42 (130.07) | 701.09* (44.26) | 25.64*# (0.90) | 5,610.73*# (188.29) | 3,511.53* (121.10) | 8,612.62*# (355.80) | 1,029.21 (122.45) |