Effects of TAT-Pyk2-CT on reduced transthoracic static compliance caused by intratracheal administration of LPS. Mice were pretreated with 10 mg/kg TAT-Pyk2-CT or TAT-GFP 1 h before saline or 10 mg/kg LPS challenge, and (A) pressure-volume (P-V) curves were generated at 18 h after challenge. B. Decrease in transthoracic static compliance caused by LPS treatment. Measurements were means ± SEM at 10 cm H2O for each group (n = 6). #P < 0.05 vs. saline control group; *P < 0.05 vs. LPS alone group.