Effect of Pyk2 inhibition on lung gross anatomy (A) and histology (B) of LPS-challenged mice. Mice were given an i.p. administration of 10 mg/kg TAT-Pyk2-CT or TAT-GFP 1 h prior to an i.t. administration of LPS. Saline challenged mice were used as negative control (Con). The lung was photographed and prepared for H&E staining 18 h after saline or LPS challenge. Representative image from one of six mice per experimental group was shown. Scale bar: 50 μm.