Effect of β2-adrenergic receptor gene (ADRB2) 3′ untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response

Table 3 Number of patients with severe asthma exacerbations in each poly-C repeat genotype group

Poly-C genotype	10a/ 11a	10a/ 12a	11a/ 11a	10a/ 13b	11a/ 12a	11a/ 13b	12a/ 12a	11a/ 14b	12a/ 13b	12a/ 14b	13b/ 13b	13b/ 14b	Genotypes <1%	Undetermined
Patients, n	44	57	225	62	314	418	136	74	356	75	211	119	98	58
Patients with ≥1 severe exacerbation, n (%)	4 (9)	3 (5)	26 (12)	5 (8)	29 (9)	48 (11)	12 (9)	10 (14)	32 (9)	14 (19)	21 (10)	19 (16)	13 (13)	7 (12)
Total number of severe exacerbations	4	3	50	8	43	66	14	12	39	25	25	22	16	21
Number of exacerbations per patient/6 months	0.13	0.06	0.32	0.14	0.15	0.24	0.11	0.18	0.13	0.37	0.16	0.20	0.18	0.39

Severe exacerbations were defined as deterioration in asthma leading to hospitalization, emergency department treatment, or oral glucocorticosteroid treatment lasting three or more days. Data includes all patients with available data of all races and all treatment arms combined (total n = 2,247; all patients with data postrandomization).

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