Figure 2

Change in morning PEF, FEV _1, rescue medication use, symptom scores, and nighttime awakenings by poly-C repeat genotype. Data includes patients with poly-C repeat genotype frequencies >1% for all races and treatments with available data. Plots show least square means and 95% confidence intervals for each poly-C repeat genotype group from ANOVA models. Models include baseline, treatment, and country as covariates. For change in morning PEF (A), FEV₁ (B), rescue medication use (C), daily symptom score (D), and nighttime awakenings (E), the total number of patients was 2,094, with 10a/11a n = 44, 10a/12a n = 57, 10a/13b n = 62, 11a/11a n = 225, 11a/12a n = 314, 11a/13b n = 418, 11a/14b n = 74, 12a/12a n = 136, 12a/13b n = 357, 12a/14b n = 77, 13b/13b n = 211, and 13b/14b n = 119. For FEV₁ (B), the total number of patients was 2,041, with 10a/11a n = 41, 10a/12a n = 56, 10a/13b n = 60, 11a/11a n = 219, 11a/12a n = 305, 11a/13b n = 406, 11a/14b n = 73, 12a/12a n = 136, 12a/13b n = 349, 12a/14b n = 75, 13b/13b n = 202, and 13b/14b n = 110. ANOVA = analysis of variance; FEV₁ = forced expiratory volume in one second; PEF = peak expiratory flow.