Table 1 Baseline demographic data
From: Bacteria in sputum of stable severe asthma and increased airway wall thickness
Parameters | Asthma with postive bacteria (n = 29) | Asthma without positive bacteria (n = 27) | P value |
|---|---|---|---|
Age (years) | 54.1 ± 13.4 | 51.9 ± 123.8 | NS |
Gender (male) | 31.0% | 33.3% | NS |
BMI, kg/m2 | 29.8 ± 6.1 | 28.8 ± 5.4 | NS |
BSA, m2 | 2.0 ± 0.3 | 1.9 ± 0.3 | NS |
Obesity % | 37.9% | 33.3% | NS |
Duration of asthma (years) | 32.9 ± 17.2 | 20.5 ± 16.0* | P < 0.05 |
Smoking % (current and past) | 34.5% | 48.1% | NS |
Nasal diseases% | 20.7% | 37.0% | NS |
Atopy % | 41.4% | 44.4% | NS |
Oral prednisolone % | 72.4% | 74.0% | NS |
Daily prednisolone (mg.day-1) | 18.5 ± 16.1 | 19.1 ± 14.3 | NS |
Inhaled BDP dose-equivalent (mg.day-1) | 2.2 ± 1.0 | 2.0 ± 0.7 | NS |
Hospitalizations in past year (Median, IQR) | 2.0 (1.3-4.8) | 0.5 (0.0-3.25) | NS |
Exacerbations in past year (Median, IQR) | 6.0 (4.3-11.5) | 3.0 (2.0-5.0) | P < 0.01 |
FEV1, l | 1.8 ± 0.6 | 2.1 ± 1.0 | NS |
FEV1% predicted | 65.0 ± 20.3% | 73.4 ± 27.9% | NS |
FVC, l | 3.1 ± 1.0 | 3.4 ± 1.2 | NS |
FVC% predicted | 92.3 ± 19.3% | 95.4 ± 18.0% | NS |
TLC % predicted | 105.2 ± 13.9 | 111.9 ± 8.2 | NS |
RV % predicted | 132.6 ± 32.4 | 148.9 ± 41.0 | NS |
RV/TLC % | 43.6 ± 9.5 | 45.0 ± 10.3 | NS |
KCO % predicted | 92.1 ± 14.6 | 92.4 ± 12.0 | NS |
Blood eosinophil count (109/L) | 0.3 ± 0.3 | 0.2 ± 0.2 | NS |
Serum IgE, IU/ml | 118.0 (23.2-400.8) | 149.5 (29.8-304.8) | NS |
Serum IgG, g/L | 9.3 ± 3.4 | 9.5 ± 2.7 | NS |
Serum IgA, g/L | 2.3 ± 0.9 | 2.3 ± 0.8 | NS |
Serum IgM, g/L | 1.1 ± 0.5 | 1.2 ± 0.5 | NS |