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Table 3 Prognostic factors contributing to annual changes in FEV 1 in multivariate random coefficient model: Sub-analysis of 119 patients whose history of exacerbations was recorded for one year before study entry

From: Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease

 

Estimate*

95% Confidence interval

p-value

Age, per 1-year increase

0.88

(0.04 to 1.71)

0.040

Height, per increase of 1 cm

0.13

(−1.06 to 1.31)

0.83

Weight, per increase of 1 kg

−0.09

(−1.00 to 0.81)

0.84

%FEV1, per 1% increase

−0.87

(−1.44 to −0.31)

0.003

RV/TLC (%)

0.03

(−1.11 to 1.18)

0.95

DLCO/VA (mL/min/mmHg/L)

−1.50

(−10.48 to 7.48)

0.74

Continuous smoking, yes/no

−22.76

(−40.13 to −5.40)

0.011

LAV%, per 1% increase

−2.62

(−4.04 to −1.20)

0.0004

SD-LAV, per 1% increase

3.32

(0.54 to 6.10)

0.020

WA%, per 1% increase

−0.48

(−1.56 to 0.60)

0.26

Proxy for inspiration†, per increase of 0.1

−0.79

(−6.76 to 5.18)

0.79

History of frequent exacerbation in previous year, yes/no

5.91

(−13.10 to 24.91)

0.54

  1. Frequent exacerbation is defined as at least two exacerbations per year.
  2. Abbreviations: %FEV1, percent predicted FEV1; RV/TLC, ratio of residual volume to total lung capacity; DLCO/VA, ratio of diffusing capacity to alveolar ventilation; LAV%, ratio of low attenuation volume to total lung volume; SD-LAV, standard deviation of LAV% values in 10 partitions with equal volumes; WA%, wall area percent in right apical bronchus;
  3. †Proxy for inspiration was defined as the ratio of CT derived total lung volume to physiologically-measured total lung capacity for estimating inspiration levels during CT scan.
  4. * Regression coefficients for interactions with time, negative value indicates excess annual decline in FEV1.