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Table 5 Haplotype-based association analysis of TRPV1 haplotypes and usual cough in 2046 subjects without asthma

From: Transient receptor potential genes, smoking, occupational exposures and cough in adults

Haplotype

Haplotype frequency

OR (95%CI)

P value

AGGCGCCAG

0.224

1.00 (reference)

 

GGGTGCTAT

0.158

1.25 (0.92-1.71)

0.152

GGGTGCCAG

0.140

1.53 (1.13-1.08)

0.006*

GGATTCCGT

0.123

1.54 (1.11-2.14)

0.010

GGATGCTAT

0.099

1.24 (0.87-1.77)

0.241

GAATGTCGT

0.070

1.60 (1.09-2.35)

0.016

Rare haplotypes

0.186

1.15 (0.84-1.58)

0.382

  1. Haplotypes are a combination of 9 adjacent SNPs: rs17706630 G/A - rs222748 G/A - rs150846 G/A - rs2277675 T/C - rs161381 G/T - rs222738 C/T - rs17707155 C/T - rs222741 A/G - rs150854 T/G. OR and 95% CI are adjusted for age, sex, smoking habits, occupational exposure, principal components for within-Europe diversity, study, and sample. *Significant after Bonferroni correction (0.05/6 = 0.0083)