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Table 4 Haplotype-based association analysis of TRPV1 haplotypes and nocturnal cough in 2046 subjects without asthma

From: Transient receptor potential genes, smoking, occupational exposures and cough in adults

Haplotype

Haplotype frequency

OR (95%CI)

P value

TTGGAGG

0.227

1.00 (reference)

 

CCAAGGG

0.131

1.26 (0.97-1.64)

0.085

CCGGGGA

0.120

1.54 (1.18-2.02)

0.001*

TCAAGGG

0.090

1.40 (1.04-1.90)

0.027

TCAGGGA

0.087

1.55 (1.14-2.10)

0.004*

CCGGGGG

0.079

1.51 (1.10-2.05)

0.010

TCAAGAA

0.061

1.53 (1.08-2.16)

0.016

Rare haplotypes

0.205

1.19 (0.93-1.53)

0.161

  1. Haplotypes are a combination of 7 adjacent SNPs: rs8065080 T/C - rs161365 C/T - rs150908 G/A - rs224534 G/A - rs17706630 G/A - rs222748 G/A - rs150846 G/A. OR and 95% CI are adjusted for age, sex, smoking habits, occupational exposure, principal components for within-Europe diversity, study, and sample. *Significant after Bonferroni correction (0.05/7 = 0.007)