Table 3 Association of TRPV1 SNPs with nocturnal cough, usual cough, and chronic cough under an additive model in 844 adults with asthma and 2046 adults without asthma
From: Transient receptor potential genes, smoking, occupational exposures and cough in adults
Subjects with asthma | Subjects without asthma | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP | Region | Alleles† | MAF | Nocturnal cough | Usual cough | Chronic cough | Nocturnal cough | Usual cough | Chronic cough |
rs4790522 | 3'UTR | C/A | 0.41 | 0.97 (0.78-1.20) | 1.35 (1.09-1.67) | 1.19 (0.92-1.55) | 1.20 (1.03-1.39) | 1.31 (1.10-1.57) | 1.01 (0.77-1.31) |
rs16953163 | intron | A/G | 0.20 | 0.95 (0.73-1.23) | 0.83 (0.64-1.09) | 0.81 (0.58-1.12) | 1.10 (0.92-1.30) | 1.08 (0.88-1.34) | 1.15 (0.84-1.57) |
rs224546 | intron | T/C | 0.42 | 0.96 (0.77-1.18) | 1.27 (1.03-1.58) | 1.07 (0.83-1.39) | 1.16 (1.00-1.35) | 1.09 (0.91-1.30) | 0.89 (0.68-1.15) |
rs11655540 | intron | T/G | 0.35 | 1.03 (0.83-1.28) | 0.89 (0.71-1.10) | 1.03 (0.79-1.34) | 0.77 (0.66-0.90) * | 0.85 (0.70-1.03) | 1.09 (0.83-1.43) |
rs161364 | intron | C/T | 0.28 | 0.93 (0.73-1.17) | 1.12 (0.89-1.42) | 1.11 (0.84-1.47) | 1.09 (0.93-1.29) | 1.22 (1.01-1.49) | 1.13 (0.84-1.52) |
rs8065080 | Ile585Val | T/C | 0.39 | 0.94 (0.76-1.15) | 0.94 (0.76-1.15) | 0.91 (0.70-1.18) | 1.15 (0.99-1.33) | 0.92 (0.77-1.10) | 0.90 (0.69-1.19) |
rs161365 | intron | C/T | 0.32 | 1.11 (0.89-1.39) | 0.91 (0.73-1.15) | 0.86 (0.66-1.13) | 0.72 (0.62-0.85)* ‡ | 0.85 (0.70-1.05) | 1.02 (0.76-1.38) |
rs150908 | intron | G/A | 0.44 | 0.87 (0.71-1.07) | 1.00 (0.81-1.23) | 0.94 (0.73-1.20) | 1.10 (0.95-1.28) | 1.23 (1.03-1.48) | 1.21 (0.93-1.58) |
rs224534 | Thr469Ile | G/A | 0.35 | 0.86 (0.69-1.06) | 0.90 (0.73-1.11) | 0.97 (0.76-1.25) | 1.01 (0.87-1.18) | 1.14 (0.96-1.36) | 1.24 (0.96-1.61) |
rs17706630 | intron | G/A | 0.27 | 1.02 (0.81-1.30) | 0.95 (0.75-1.21) | 1.00 (0.76-1.32) | 0.71 (0.59-0.84)* ‡ | 0.73 (0.59-0.92) ‡ | 0.71 (0.50-0.99) |
rs222748 | His167His | G/A | 0.11 | 1.00 (0.72-1.40) | 0.92 (0.66-1.28) | 1.20 (0.82-1.76) | 0.97 (0.76-1.23) | 1.18 (0.89-1.56) | 1.32 (0.88-1.97) |
rs150846 | intron | G/A | 0.36 | 1.12 (0.91-1.38) | 1.08 (0.87-1.33) | 1.11 (0.85-1.44) | 1.22 (1.05-1.41) | 1.18 (0.99-1.42) | 1.25 (0.96-1.62) |
rs2277675 | 5'UTR | T/C | 0.28 | 1.17 (0.93-1.46) | 0.97 (0.77-1.21) | 1.04 (0.79-1.35) | 0.73 (0.62-0.86)* ‡ | 0.64 (0.52-0.80)* ‡ | 0.64 (0.46-0.90) |
rs161381 | 5'UTR | G/T | 0.15 | 1.05 (0.79-1.39) | 1.21 (0.91-1.61) | 1.06 (0.75-1.50) | 1.20 (0.98-1.47) | 1.19 (0.93-1.51) | 1.07 (0.75-1.55) |
rs222738 | 5'UTR | C/T | 0.09 | 0.99 (0.69-1.40) | 0.93 (0.64-1.33) | 1.14 (0.73-1.77) | 0.84 (0.65-1.09) | 1.12 (0.82-1.51) | 1.37 (0.89-2.09) |
rs17707155 | 5'UTR | C/T | 0.28 | 0.91 (0.73-1.14) | 0.97 (0.77-1.21) | 0.99 (0.75-1.31) | 1.23 (1.05-1.43) | 1.01 (0.83-1.22) | 1.05 (0.78-1.40) |
rs222741 | 5' | A/G | 0.24 | 1.07 (0.85-1.34) | 1.15 (0.90-1.46) | 1.11 (0.83-1.50) | 1.10 (0.93-1.30) | 1.23 (1.01-1.51) | 1.40 (1.04-1.88) |
rs150854 | 5' | T/G | 0.46 | 1.12 (0.91-1.37) | 0.96 (0.78-1.18) | 0.94 (0.73-1.21) | 0.74 (0.64-0.86)* ‡ | 0.84 (0.70-1.00) | 0.76 (0.57-1.00) |
rs224498 | 5' | T/G | 0.39 | 0.93 (0.76-1.15) | 1.16 (0.94-1.43) | 0.99 (0.76-1.27) | 1.32 (1.14-1.53)* ‡ | 1.11 (0.92-1.33) | 1.00 (0.76-1.31) |