In vivo measurements in the course of time (LPS = lipopolysaccharide; LTV = low tidal volume, HTV = high tidal volume). A. Mean arterial pressure decreased by LPS treatment (P = 0.011). B. Central venous pressure increased by MV with high Vt (P = 0.001). C. Cardiac output decreased by MV with high Vt (P = 0.004). D Plateau pressure increased by MV with high Vt (P < 0.001) E. PaO2/FIO2 ratios were similar in the groups.