Figure 2

Influence of MAPK inhibitors on H ₂ O ₂ + IFNγ induced IL-32 mRNA expression in HBE cells. After treatment with the JNK inhibitor, the MEK inhibitor, the p38 inhibitor for 24 hours, IL-32 mRNA expression in H₂O₂ and IFNγ stimulated HBE cells (A) and the effect of JNK inhibitor (B) or JAK inhibitor I (C) upon IL-32 expression stimulated by IFNγ with or without H₂O₂ in HBE cells were examined by quantitative real-time PCR. All mRNA quantities were adjusted to the quantities at 0 hour control without stimulation. In graph (B) and (C), the closed bars represent the results of vehicle control and the open bars represent the results of JNK inhibitor (B) and JAK inhibitor (C). The bars show the means ± SE from 3 different individuals. *p < 0.05 significantly different.