Association of IREB2 and CHRNA3polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

Table 3 Genetic association results between SNPs in chromosome 15 and lung function of male subgroup in the AAT Genetic Modifiers Study cohort

P-Values for Different Phenotypes
Gene	SNP		pre-FEV₁% predicted	post-FEV₁% predicted	pre- FEV₁/FVC	post- FEV₁/FVC
IREB2	rs2568494	intron	0.03*	0.04*	0.07	0.03*
	rs2656069	intron	0.97	0.87	0.64	0.65
	rs1964678	intron	0.99	0.96	0.85	0.78
	rs12593229	intron	0.95	0.93	0.87	0.76
	rs10851906	intron	0.70	0.61	0.84	0.80
	rs965604	intron	0.84	0.90	0.75	0.70
	rs13180	exon	0.85	0.91	0.76	0.71
LOC123688	rs8034191	intron	0.04*	0.04*	0.12	0.04*
CHRNA3	rs1051730	exon	0.02*	0.02*	0.07	0.02*

Each model was analyzed assuming an additive mode of inheritance adjusting for pack-years and pack-years²
* p ≤ 0.05

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