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Table 1 Baseline characteristics for PI ZZ individuals in the AAT Genetic Modifiers Study and the UK AATD National Registry

From: Association of IREB2 and CHRNA3polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

Characteristics

AAT Genetic Modifiers Study

(n= 378)

UK national registry for AATD

(n= 458)

pvalue

Age, years

52.2 ± 9.7

50.3 ± 10.4

0.01

Male sex (%)

173 (46%)

252 (55%)

< 0.0001

FEV1% predicted

65.9 ± 33.5

53.8 ± 32.2

0.0001

FEV1/FVC

0.551 ± 0.207

0.445 ± 0.194

< 0.0001

Pack-years for ever smokers

18.2 ± 14.5

15.9 ± 14.7

< 0.0001

  1. Data are presented as means (± S.D.) in the AAT Genetic Modifiers Study and the UK national registry for AATD, unless otherwise noted