Table 1 Patients characteristics
Asthmatic patients | Controls | p | |
|---|---|---|---|
n | 32 | 20 | |
Age (yr) | 12.5 (11.0-15.0) | 13.5 (12.0-15.8) | ns |
Female (n) | 11 | 12 | ns |
Atopy (n) | 30 | 0 | |
Passive smoking | 9 | 7 | ns |
Treatment | |||
ICS (n) | 17 | ||
Beclomethasone | |||
equivalent dosage (μg) | 200 (0-400) | ||
Budesonide (n) | 13 | ||
Fluticasone (n) | 4 | ||
Bronchodilator (n) | 12 | ||
Salbutamol | 4 | ||
Formeterol | 8 | ||
Montelukast (n) | 3 | ||
FEV 1 (% pred.) | 105 (97-118) | 107 (101-116) | ns |
VC (% pred.) | 103 (96-112) | 101 (89-99) | ns |
MEF 25 (% pred.) | 104 (83-115) | 100 (79-113) | ns |
MEF 50 (% pred.) | 94 (76-126) | 104 (84-124) | ns |
MEF 75 (% pred.) | 92 (75-117) | 125 (91-158) | ns |
TLC (% pred.) | 98 (85-104) | 92 (87-100) | ns |
ITV (% pred.) | 101 (82-113) | 101 (86-121) | ns |
RV/TLC (% pred.) | 88 (71-98) | 92 (73-99) | ns |
sR aw, tot (kPa*s) | 0.67 (0.50-0.91) | 0.50 (0.44-0.63) | ns |
FE NO (ppb)* | 17.0 (8.0-39.3) | 9.0 (7.0-11.0) | 0.001 |
ACT (points) | |||
< 12 years (n = 11) | 25 (22-26) | ||
≥ 12 years (n = 21) | 23 (21-25) | ||
H 2 O 2 concentrations airway fraction (nmol/L) | 290 (155-505) | 310 (115-555) | ns |
H 2 O 2 concentrations alveolar fraction (nmol/L) | 220 (140-460) | 180 (120-320) | ns |