Skip to main content

Table 2 Pulmonary function test of patients with and without COPD according to the expert panel and the GOLD definition

From: "GOLD or lower limit of normal definition? a comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study"

 

All Subjects

Expert Panel

P

GOLD definition

P

 

(n = 405)

No COPD (n = 158)

COPD (n = 247)

 

No COPD (n = 161)

COPD (n = 244)

 

Pre-bronchodilator Pulmonary Function Test

FEV1, %

76 (57; 96)

100 (92; 111)

62 (48; 75)

< 0.001

99 (84; 110)

63 (48; 79)

< 0.001

FVC, %

95 (78; 109)

109 (99; 120)

84 (74; 96)

< 0.001

104 (91; 117)

88 (76; 102)

< 0.001

FEV1/FVC

0.66 (0.55; 0.74)

0.75 (0.7; 0.8)

0.58 (0.48; 0.66)

< 0.001

0.75 (0.71; 0.8)

0.58 (0.48; 0.65)

< 0.001

TLC, %

110 (100; 122)

107 (98; 116)

113 (102; 125)

< 0.001

105 (97; 114)

114 (104; 125)

< 0.001

RV, %

126 (106; 159)

108 (94; 121)

146 (120; 175)

< 0.001

108 (96; 126)

142 (117; 174)

< 0.001

RV/TLC, %

114 (99; 132)

99 (92; 108)

124 (112; 140)

< 0.001

102 (93; 115)

122 (108; 138)

< 0.001

DLCO, %

72 (58; 83)

81 (71; 91)

63 (49; 76)

< 0.001

78 (67; 89)

66 (50; 79)

< 0.001

Post-bronchodilator Pulmonary Function Test

FEV1, %

82 (64; 102)

106 (97; 116)

69 (56; 81)

< 0.001

103 (89; 115)

70 (56; 85)

< 0.001

FVC, %

102 (88; 117)

114 (103; 125)

92 (80; 108)

< 0.001

105 (91; 120)

98 (85; 115)

0.004

FEV1/FVC

0.66 (0.55; 0.75)

0.76 (0.71; 0.81)

0.58 (0.48; 0.66)

< 0.001

0.77(0.74; 0.81)

0.57 (0.47;0. 65)

< 0.001

  1. Data are shown as median (25th; 75th percentile). All PFT variables except FEV1/FVC are presented as percentage of predicted. P-value refers to Mann-Whitney-U test.
  2. Abbreviations: DLCO, diffusion capacity of carbon monoxide, FEV1, forced expiratory volume in 1 second, FVC, forced vital capacity, RV, residual volume, TLC, total lung capacity.