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Table 3 Serum analytes significantly elevated in COPD among older current smokers

From: Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease

Analytea

T54 COPD/Ctr1b

BioServe COPD/Ctr1

T54 COPD/Ctr2

BioServe COPD/Ctr2

 

Fold/controlc

FDRc

Fold/control

FDR

Fold/control

FDR

Fold/control

FDR

COPD > Control

        

CD40 Ligand

102.5

< 10-8

282.0

< 10-8

102.5

< 10-8

282.0

< 10-8

EGF

16.3

< 10-8

48.3

< 10-8

71.5

< 10-8

211.5

< 10-8

BDNF

54.0

< 10-8

63.9

< 10-8

58.5

< 10-8

69.3

< 10-8

RANTES

12.0

< 10-8

16.9

< 10-8

14.1

< 10-8

19.8

< 10-8

Myeloperoxidase

6.8

< 10-8

24.2

< 10-8

6.5

< 10-8

23.1

< 10-8

Eotaxin

8.9

< 10-8

10.8

< 10-8

8.9

< 10-8

10.8

< 10-8

EN-RAGE

3.1

< 10-8

25.5

< 10-8

2.3

1.5 × 10-5

19.4

< 10-8

Ferritin

5.6

< 10-8

8.7

< 10-8

2.9

< 10-8

4.5

< 10-8

IL-1RA

5.6

< 10-8

28.4

< 10-8

3.5

< 10-8

17.6

< 10-8

ENA-78

5.9

< 10-8

8.1

< 10-8

7.8

< 10-8

10.8

< 10-8

PAI-1

7.5

< 10-8

8.1

< 10-8

5.3

< 10-8

5.7

< 10-8

MCP-1

2.8

< 10-8

2.8

< 10-8

4.5

< 10-8

4.5

< 10-8

MIP-1beta

2.5

< 10-8

3.4

< 10-8

2.6

< 10-8

3.5

< 10-8

Thrombopoietin

2.9

< 10-8

3.1

< 10-8

2.9

< 10-8

3.1

< 10-8

TIMP-1

2.7

< 10-8

3.0

< 10-8

3.1

< 10-8

3.3

< 10-8

IL-16

1.8

< 10-8

5.7

< 10-8

1.7

< 10-8

5.4

< 10-8

VEGF

2.1

< 10-8

2.9

< 10-8

2.6

< 10-8

3.6

< 10-8

Cancer antigen 19-9

2.0

0.0026

2.2

0.0084

1.6

0.18

1.8

0.25

CD40

1.7

< 10-8

3.1

< 10-8

1.7

< 10-8

3.2

< 10-8

Creatine kinase-MB

2.1

0.0023

2.3

0.0006

2.1

0.044

2.3

0.0063

C-reactive protein

1.7

0.019

2.0

0.0076

1.7

0.077

2.0

0.036

Myoglobin

2.1

9.2 × 10-6

1.8

0.0011

1.4

0.0023

1.2

0.074

Stem cell factor

1.7

< 10-8

1.8

< 10-8

1.9

< 10-8

2.1

< 10-8

IL-18

1.7

< 10-8

2.4

< 10-8

1.4

4.5 × 10-6

2.0

< 10-8

TNF-RII

1.4

< 10-8

1.7

< 10-8

1.5

< 10-8

1.8

< 10-8

COPD < Control

        

IGF-1

-6.0

0.00018

-3.8

6.5 × 10-6

-6.6

8.6 × 10-6

-4.2

< 10-8

IgE

-4.1

0.025

-3.2

0.019

-3.4

0.0050

-2.6

0.0068

  1. aBaseline levels of analytes reported in Table 2 to be associated with COPD vs control, restricted to current smokers between the ages of 50 and 70, inclusive.
  2. bThe subpopulation sizes were: T54, n = 104; BioServe, n = 50; Ctr1, n = 33; Ctr2, n = 19.
  3. cFDR and signed-fold levels in COPD over controls (fold/control) are provided for each subpopulation. FDR > 0.05 are shown in bold.
  4. BDNF, brain-derived neurotrophic factor; COPD, chronic obstructive pulmonary disease; EGF, epidermal growth factor; ENA, epithelial-derived neutrophil activating protein; EN-RAGE, extracellular newly identified-receptor for advanced glycation end-binding protein; FDR, false discovery rate; IgE, immunoglobulin E; IGF, insulin-like growth factor; IL, interleukin; -MB, -muscle/brain; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; PAI, plasminogen activating factor; RA, receptor agonist; RANTES, regulated upon activation, normally T-cell expressed, and secreted; TIMP, tissue inhibitor of metalloproteinases; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.
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Respiratory Research

ISSN: 1465-993X

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