Figure 2

Baseline serum analyte concentrations in current smokers. The serum concentrations of the indicated analytes in healthy control and COPD cohorts, restricted to only current smokers, are shown for subgroups < 50 (n = 36 and 22 for controls and COPD, respectively) or between 50- to 70-years-old (n = 16 and 107 for controls and COPD, respectively). Data presented as box (median, interquartile range) and whiskers (10^th-90^th percentiles). Dotted line indicates LDD. *COPD vs control, False discovery rate < 10^-8 within 50-70 year age group. BDNF, brain-derived neurotrophic factor; CD40L, CD40 ligand; EGF, epidermal growth factor; IgE, immunoglobulin E.