Figure 1From: Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary diseaseSerum analytes associated with COPD vs controls. Hierarchical clustering (average linkage with Euclidean distances) was performed restricted to the analytes reported in Table 2 to be associated with COPD vs controls. Serum concentrations were normalized as log2 of fold over the geometric mean (Gm) of the control cohorts and presented as a heatmap with subjects across x-axis and analytes on y-axis. Disease status, smoking status, and GOLD stage are represented at bottom. IGF-1, insulin-like growth factor-1; Ig, immunoglobulin; EGF, epidermal growth factor; TNF-RII, tumor necrosis factor-receptor II; IL, interleukin; TIMP-1, tissue inhibitor of metalloproteinases-1; VEGF, vascular endothelial growth factor; EN-RAGE, extracellular newly identified-receptor for advanced glycation end-binding protein; RANTES, regulated upon activation, normally T-cell expressed, and secreted; ENA-78, epithelial-derived neutrophil activating protein-78; PAI-1, plasminogen activating factor-1; MCP-1, monocyte chemoattractant protein-1; MIP-1beta, macrophage inflammatory protein-1beta.Back to article page