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Table 4 Summary of ad hoc analyses for DCPD total score, mean change from baseline at Day 4

From: Patient-reported outcomes to assess the efficacy of extended-release guaifenesin for the treatment of acute respiratory tract infection symptoms

     Endpoint Placebo ER guaifenesin p-value
1. Excluding questions 3, 6, and 7 (SUM8)    
Overall −5.7 −7.1 0.0372
1 day since onset of symptoms −6.2 −8.4 0.0339
2 days since onset of symptoms −6.1 −7.5 0.2281
3 days since onset of symptoms −5.6 −6.2 0.4424
4 days since onset of symptoms −5.4 −7.5 0.2475
5 days since onset of symptoms −7.9 −8.0 0.6814
Diagnosis: acute rhinopharyngitis −5.9 −6.8 0.1521
Diagnosis: acute sinusitis −3.0 −8.0 0.0534
Diagnosis: acute pharyngitis −15.3 −5.5 NA
Diagnosis: acute bronchitis −4.3 −9.8 0.0064
2. Including questions 5, 8, 10, and 11 only    
Overall −3.0 −3.9 0.0059
1 day since onset of symptoms −2.9 −4.6 0.0093
2 days since onset of symptoms −3.5 −4.2 0.1499
3 days since onset of symptoms −2.7 −3.4 0.1439
4 days since onset of symptoms −2.8 −4.0 0.1342
5 days since onset of symptoms −5.3 −4.3 0.5617
Diagnosis: acute rhinopharyngitis −3.0 −3.8 0.0263
Diagnosis: acute sinusitis −1.8 −4.3 0.0715
Diagnosis: acute pharyngitis −8.7 −3.5 NA
Diagnosis: acute bronchitis −2.1 −4.7 0.0368
3. Including questions 8, 9, 10, and 11 only    
Overall −2.5 −3.2 0.0062
1 day since onset of symptoms −1.8 −4.4 0.0286
2 days since onset of symptoms −2.6 −3.4 0.0965
3 days since onset of symptoms −2.7 −2.6 0.4421
4 days since onset of symptoms −2.4 −3.1 0.2021
5 days since onset of symptoms −3.4 −4.6 0.6586
Diagnosis: acute rhinopharyngitis −2.5 −3.2 0.0176
Diagnosis: acute sinusitis −0.6 −2.6 0.1035
Diagnosis: acute pharyngitis −8.0 −2.3 NA
Diagnosis: acute bronchitis −2.1 −4.0 0.0330
  1. DCPD: Daily Cough and Phlegm Diary. Note: Items with statistically significant values are in bold. P-value is from analysis of covariance (ANCOVA) model comparing treatments within day with predictors of treatment group, center, and baseline. NA indicates that the p-value in not estimable.