Table 4 Summary of ad hoc analyses for DCPD total score, mean change from baseline at Day 4
Endpoint | Placebo | ER guaifenesin | p-value |
|---|---|---|---|
1. Excluding questions 3, 6, and 7 (SUM8) | |||
Overall | −5.7 | −7.1 | 0.0372 |
1 day since onset of symptoms | −6.2 | −8.4 | 0.0339 |
2 days since onset of symptoms | −6.1 | −7.5 | 0.2281 |
3 days since onset of symptoms | −5.6 | −6.2 | 0.4424 |
4 days since onset of symptoms | −5.4 | −7.5 | 0.2475 |
5 days since onset of symptoms | −7.9 | −8.0 | 0.6814 |
Diagnosis: acute rhinopharyngitis | −5.9 | −6.8 | 0.1521 |
Diagnosis: acute sinusitis | −3.0 | −8.0 | 0.0534 |
Diagnosis: acute pharyngitis | −15.3 | −5.5 | NA |
Diagnosis: acute bronchitis | −4.3 | −9.8 | 0.0064 |
2. Including questions 5, 8, 10, and 11 only | |||
Overall | −3.0 | −3.9 | 0.0059 |
1 day since onset of symptoms | −2.9 | −4.6 | 0.0093 |
2 days since onset of symptoms | −3.5 | −4.2 | 0.1499 |
3 days since onset of symptoms | −2.7 | −3.4 | 0.1439 |
4 days since onset of symptoms | −2.8 | −4.0 | 0.1342 |
5 days since onset of symptoms | −5.3 | −4.3 | 0.5617 |
Diagnosis: acute rhinopharyngitis | −3.0 | −3.8 | 0.0263 |
Diagnosis: acute sinusitis | −1.8 | −4.3 | 0.0715 |
Diagnosis: acute pharyngitis | −8.7 | −3.5 | NA |
Diagnosis: acute bronchitis | −2.1 | −4.7 | 0.0368 |
3. Including questions 8, 9, 10, and 11 only | |||
Overall | −2.5 | −3.2 | 0.0062 |
1 day since onset of symptoms | −1.8 | −4.4 | 0.0286 |
2 days since onset of symptoms | −2.6 | −3.4 | 0.0965 |
3 days since onset of symptoms | −2.7 | −2.6 | 0.4421 |
4 days since onset of symptoms | −2.4 | −3.1 | 0.2021 |
5 days since onset of symptoms | −3.4 | −4.6 | 0.6586 |
Diagnosis: acute rhinopharyngitis | −2.5 | −3.2 | 0.0176 |
Diagnosis: acute sinusitis | −0.6 | −2.6 | 0.1035 |
Diagnosis: acute pharyngitis | −8.0 | −2.3 | NA |
Diagnosis: acute bronchitis | −2.1 | −4.0 | 0.0330 |