Table 2 Patient characteristics and inflammatory mediators in sputum according to bronchial colonization by Haemophilus influenzae (n=116)
| Â | Non-colonized | Colonized by H. influenzae | p value* |
|---|---|---|---|
| Â | n=94 | n=22 | - |
Patient characteristics | Â | Â | Â |
Age (years), mean (SD) | 69 (9) | 70 (8) | 0.880 |
Current smoker, n (%) | 24 (26) | 6 (27) | 0.932 |
Smoking pack-years, median (P25-P75) | 58 (36-90) | 103 (60-138) | 0.002 |
FEV1 post-BD % pred, mean (SD) | 52 (16) | 50 (15) | 0.597 |
Inhaled corticosteroids, n (%) | 11 (12) | 2 (9) | 0.727 |
Inflammatory mediators in sputum | Â | Â | Â |
Total cells/ml × 106, median (P25-P75) | 12 (4-24) | 7 (4-22) | 0.388 |
Neutrophils/ml ×106, median (P25-P75) | 7 (2-18) | 4 (1-14) | 0.526 |
IL-1β (pg/ml), median (P25-P75) | 154 (41-485) | 746 (121-1802) | <0.001 |
IL-6 (pg/ml), median (P25-P75) | 109 (50-201) | 168 (53-436) | 0.172 |
IL-8 (×103) (pg/ml), median (P25-P75) | 8 (3-15) | 16 (11-22) | < 0.001 |