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Table 5 Studies which report asthma hospitalization/ED visit, maintenance medications use (steroid or salbutamol) etc

From: Statins as potential therapeutic drug for asthma?

Study Study type Group Sample (Trial/Control) Duration of treatment Results (statin group compared with the control group)
Huang et al., [30] Retrospective study Statin exposed vs statin unexposed 11808(3965/7843) 4.66 ± 2.32 years Hospitalization/ED visit (p=0.006) ↓
Ostroukhova et al., [18] Retrospective study Statin exposed vs statin unexposed 50(24/26) 2 years Maintenance medication (p=0.005), nocturnal awakenings(P=0.001), office visits(P=0.003) and albuterol use (p=0.001) ↑
Christiansen et al., [17] Retrospective study Statin exposed vs statin unexposed 43158(7783/35375) Not mentioned Risk ratios were 1.2 for Hospitalizations/ED visits and 1.17 for oral corticosteroid diepemsing ↑
Stanek et al., [13] Retrospective study Statin exposed vs statin unexposed 6574(2103/4471) 1 year Hospitalization/ED visit (p < 0.001) ↓
Moskovljevic et al., [28] Controlled clinical trial Atorvastatin(10mg/day) vs placebo 9 4 weeks Morbidity ↓
Pagovich et al., [26] Retrospective study Atorvastatin, simvastatin vs baseline 70 4 weeks Albuterol use(p<0.0001) ↓
Fahimi et al., [23] RCT Atorvastatin(10mg/day) vs placebo 17 4 weeks Morbidity (p=0.42) ↓
Feschenko et al., [14] RCT Atorvastatin+ICS+Salbutamol vs ICS+salbutamol 31 4 weeks Night symptoms, cough, dialy symptoms and use of salbutamol (p<0.05) ↓
Lokhandwala et al., [31] Retrospective study Statin exposed vs statin unexposed 1437(479/958) 1 year Hospitalization/ED visit (p=0.0059) ↓
  1. ↑ Statin have bad effects on asthma patients, ↓ an opposite result.