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Table 1 Subject characteristics of UCSF cohort

From: Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis

Variable

IPF

HP

NSIP

 

(n = 84)

(n = 24)

(n = 22)

Age, years

70.3 (7.9)

57.0 (10.3)*

63.6 (12.5)*

Male sex, %

76.2

33.3*

59.1

Diagnosis by surgical lung biopsy, %

50.0

66.7

72.7

Smoking history

   

Ever smoked, %

78.6

41.7*

31.8*

Pack-years

27.7 (28.7)

11.8 (18.8)*

6.4 (13.8)*

Measures of disease severity

   

Dyspnea score

9.8 (6.0)

11.2 (4.6)

9.6 (4.4)

Long-term oxygen therapy, %

20.2

23.8

27.3

Pulmonary function

   

FVC, % predicted

69.4 (18.2)

67.3 (22.0)

64.1 (19.1)

DLCO, % predicted

46.7 (18.4)

55.1 (21.2)

43.7 (14.4)

  1. Data shown are mean (standard deviation), unless otherwise indicated.
  2. * p < 0.05 for comparison with the IPF cohort.
  3. Abbreviations: DLCO, diffusing capacity of carbon monoxide; FVC, forced vital capacity; HP, hypersensitivity pneumonitis; IPF, idiopathic pulmonary fibrosis; NSIP, nonspecific interstitial pneumonia; UCSF, University of California San Francisco.