Figure 1From: Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosisThe UPR is activated in type II AECs isolated from IPF lungs. Phosphorylated IRE-1α (panel A) and spliced XBP-1 (panel B) were present in increased amounts in AECs from 3 different IPF lungs, but not in the 3 control subjects (* P < 0.05, **P = 0.0495 by Wilcoxon rank sum test). # indicates amplicon of unspliced XBP1 digested with Pst1.Back to article page