Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs

Respiratory Research

Table 6 Summarized events (reactions and/or pathways) and the expression patterns in previously rat models

ID^*	Event Name^†	Hypoxia-induced model^‡	Hypoxia-induced model^§	MCT-induced model^¶
map04630	JAK/STAT signaling	Not identified	Not identified	Not identified
REACT_604	Hemostasis	Down	Up/Down	Up/Down
GO:0030520	Estrogen receptor signaling pathway	Up	Not identified	Down
GO:0007210	Serotonin receptor signaling pathway	Up/Down	Not identified	Down
GO:0001666	Response to hypoxia	Up/Down	Up	Down
map04310	Wnt/PCP pathway	Not identified	Not identified	Not identified
REACT_19389	ROCK activation by Rho	Up	Not identified	Down
REACT_16888	Signaling by PDGF	Up	Up/Down	Down
REACT_12529	Signaling by VEGF	Not identified	Not identified	Down
GO:0042981	Regulation of apoptotic process	Up/Down	Not identified	Up/Down
REACT_12034	Signaling by BMP	Up/Down	Not identified	Not identified
REACT_6844	Signaling by TGF beta	Up	Up	Up

*Accession number of Reactome, KEGG, and GO.
^†Event name according to the Reactome, KEGG, and GO Database.
^‡Hypoxia-induced rat models reported by Moreno-Vinasco et al [31].
^§Hypoxia-induced rat models reported by Kwapiszewska et al [32].
^¶MCT-induced rat models reported by Vaszar et al [33].
JAK/STAT: Janus kinase-signal transducer and activator of transcription, PCP: planar cell polarity, ROCK: Ras Homolog- Associated Coiled-Coil-Forming Protein Kinase, Rho: Ras Homolog, PDGF: Platelet-derived growth factor, VEGF: Vascular endothelial growth factor, BMP: Bone morphogenetic protein, TGF: Transforming growth factor, MCT: Monocrotaline.

ISSN: 1465-993X