Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs

Respiratory Research

Table 5 Events (reactions and/or pathways) and the expression patterns in IPAH and in our PAH model

ID*	Event Name^†	IPAH^‡	Present model
map04630	JAK/STAT signaling	Up	UP
REACT_604	Hemostasis	Up	Up
GO:0030520	Estrogen receptor signaling pathway	Up	Up
GO:0007210	Serotonin receptor signaling pathway	Up	Up
GO:0001666	Response to hypoxia	Up	Not identified
map04310	Wnt/PCP pathway	Up	Not identified
REACT_19389	ROCK activation by Rho	Up	Not identified
REACT_16888	Signaling by PDGF	Up	Down
REACT_12529	Signaling by VEGF	Up	Down
GO:0042981	Regulation of apoptotic process	Up/Down	Down
REACT_12034	Signaling by BMP	Down	Down
REACT_6844	Signaling by TGF beta	Down	Not identified

*Accession number of Reactome, KEGG, and GO.
^†Event name according to the Reactome, KEGG, and GO Database.
^‡Expression pattern of biological molecules associated with the event in lung tissue obtained from patients with IPAH in previously published reports
JAK/STAT: Janus kinase-signal transducer and activator of transcription, PCP: planar cell polarity, ROCK: Ras Homolog- Associated Coiled-Coil-Forming Protein Kinase, Rho: Ras Homolog, PDGF: Platelet-derived growth factor, VEGF: Vascular endothelial growth factor, BMP: Bone morphogenetic protein, TGF: Transforming growth factor.

ISSN: 1465-993X