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Table 7 Sensitivity and Specificity of using the pre-bronchodilator lower limit of normal and using the pre-bronchodilator lower limit of normal with an added constant compared with the lower limit of normal derived from the post bronchodilator values

From: Can spirometric norms be set using pre- or post- bronchodilator test results in older people?

 

<LLN using pre-bronchodilator

<LLN using pre-bronchodilator + K

 

Sensitivity

Specificity

Youden’s index

Sensitivity

Specificity

Youden’s index

FEV1

78.4%

100%

0.78

99%

99.8%

0.99

FEV6

96.1%

100%

0.96

98%

99.8%

0.98

FVC

99.8%

99.1%

0.99

97.4%

99.9%

0.97

FEV1/FVC

65.0%

100%

0.65

98.7%

99.5%

0.98

  1. Results for 5246 subjects in the “non-normal” survey population. The participants included were those with adequate spirometry, but excluded from the estimation of normal values because of a history of smoking or of respiratory diagnosis or symptoms.
  2. Values of “K”.
  3. for FEV1 (mLs): 121 (men); 69 (women).
  4. for FEV6 (mLs): 18 (men); 3 (women).
  5. for FVC (mLs): -29 (men); -27 (women).
  6. for FEV1/FVC (%) : 3.22 (men); 2.68 (women).