Variables | Â | Odds ratio | 95% CI | P-value |
---|---|---|---|---|
Univariate analysis | Â | Â | Â | Â |
   Age (years) | ≥ 60/< 60 | 1.758 | 0.626-6.256 | 0.301 |
   Gender | Male/Female | 1.472 | 0.593-3.848 | 0.406 |
   Histological type | Non-ADC/ADC | 2.342 | 0.730-6.420 | 0.142 |
   Smoking history | Never/Smoker | 1.006 | 0.402-2.516 | 0.989 |
   Performance status | ≥ 2/0-1 | 0.942 | 0.360-2.341 | 0.899 |
   No. of prior chemotherapy regimens | ≥ 2/0-1 | 0.800 | 0.277-2.053 | 0.652 |
   Prior thoracic radiotherapy | Yes/No | 0.315 | 0.017-1.575 | 0.187 |
   Preexisting pulmonary fibrosis | Yes/No | 4.683 | 1.741-12.042 | 0.003* |
   Preexisting pulmonary emphysema | Yes/No | 1.382 | 0.476-3.574 | 0.531 |
   EGFR mutation | Wild type/EGFR mutant | 1.667 | 0.497-5.594 | 0.400 |
   Types of EGFR-TKI | Gefitinib/Erlotinib | 2.043 | 0.562-5.948 | 0.253 |
   Serum KL-6 level at baseline (U/ml) | ≥ 500/< 500 | 2.096 | 0.679-7.116 | 0.199 |