Characteristics | Total | EGFR-TKIs induced ILD (+) | EGFR-TKIs induced ILD (-) | p-value |
---|---|---|---|---|
Total | 48 | 8 | 40 | Â |
Age (years) | Â | Â | Â | Â |
Mean (± SEM) |  | 67.5(± 3.6) | 66.2(± 1.8) |  |
< 60 | 12 | 2 | 10 | 1.000 |
≥ 60 | 36 | 6 | 30 |  |
Sex | Â | Â | Â | Â |
Female | 11 | 3 | 8 | 0.361 |
Male | 37 | 5 | 32 | Â |
Histologic type | Â | Â | Â | Â |
Adenocarcinoma | 37 | 5 | 32 | 0.361 |
Squamous cell carcinoma/Others | 11 | 3 | 8 | Â |
Smoking history | Â | Â | Â | Â |
Current/Former | 40 | 5 | 35 | 0.116 |
Never | 8 | 3 | 5 | Â |
Disease stage | Â | Â | Â | Â |
IV | 24 | 3 | 21 | 0.701 |
I-IIIB/Recurrence after surgery | 11 | 5 | 19 | Â |
Performance status | Â | Â | Â | Â |
≥ 2 | 26 | 5 | 21 | 0.710 |
0-1 | 22 | 3 | 19 | Â |
No. of prior chemotherapy regimens | Â | Â | Â | Â |
≥ 2 | 20 | 1 | 19 | 0.116 |
0-1 | 28 | 7 | 21 | Â |
Prior thoracic radiotherapy | Â | Â | Â | Â |
Yes | 10 | 0 | 10 | 0.177 |
No | 38 | 8 | 30 | Â |
Pattern of preexisting pulmonary fibrosis | Â | Â | Â | Â |
IPF pattern | 3 | 1 | 2 | 0.429 |
Non-IPF pattern | 45 | 7 | 38 | Â |
Preexisting pulmonary emphysema | Â | Â | Â | Â |
Yes | 24 | 3 | 21 | 0.701 |
No | 24 | 5 | 19 | Â |
EGFR mutation status | Â | Â | Â | Â |
Wild type | 9 | 5 | 4 | 0.0498* |
Mutant | 11 | 1 | 10 | Â |
(Not evaluated) | (28) | (2) | (26) | Â |
Types of EGFR-TKI | Â | Â | Â | Â |
Gefitinib | 40 | 5 | 35 | 0.116 |
Erlotinib | 8 | 3 | 5 | Â |