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Table 2 Patients' Characteristics of 48 patients with preexisting pulmonary fibrosis

From: Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease

Characteristics

Total

EGFR-TKIs induced ILD (+)

EGFR-TKIs induced ILD (-)

p-value

Total

48

8

40

 

Age (years)

    

Mean (± SEM)

 

67.5(± 3.6)

66.2(± 1.8)

 

< 60

12

2

10

1.000

≥ 60

36

6

30

 

Sex

    

Female

11

3

8

0.361

Male

37

5

32

 

Histologic type

    

Adenocarcinoma

37

5

32

0.361

Squamous cell carcinoma/Others

11

3

8

 

Smoking history

    

Current/Former

40

5

35

0.116

Never

8

3

5

 

Disease stage

    

IV

24

3

21

0.701

I-IIIB/Recurrence after surgery

11

5

19

 

Performance status

    

≥ 2

26

5

21

0.710

0-1

22

3

19

 

No. of prior chemotherapy regimens

    

≥ 2

20

1

19

0.116

0-1

28

7

21

 

Prior thoracic radiotherapy

    

Yes

10

0

10

0.177

No

38

8

30

 

Pattern of preexisting pulmonary fibrosis

    

IPF pattern

3

1

2

0.429

Non-IPF pattern

45

7

38

 

Preexisting pulmonary emphysema

    

Yes

24

3

21

0.701

No

24

5

19

 

EGFR mutation status

    

Wild type

9

5

4

0.0498*

Mutant

11

1

10

 

(Not evaluated)

(28)

(2)

(26)

 

Types of EGFR-TKI

    

Gefitinib

40

5

35

0.116

Erlotinib

8

3

5

 
  1. *p < 0.05 (Fisher's exact test)