Table 2 Time response in JF1 and C3 mice after single instillation of 20 ÎĽg Printex 90: BAL cell differentials and protein markers expressed in lung tissue at day 1 and day 7
| Â | Â | JF1/Msf | C3H/HeJ | ||
|---|---|---|---|---|---|
| Â | Â | Day1 | Day7 | Day1 | Day7 |
BAL cell differentials | PMN | ↑ | ↑ | ↑ | ↑ ↔ |
|  | Macrophages | NR | ↑ | NR | NR |
|  | Lymphocytes | NR | ↑ | NR | NR |
Lung tissue proteins | IL1B | ↑ | ↑ | ↑ | ↑ |
|  | TNF | ↑ | ↑ | ↑ | ↔ |
|  | IL4 | ↔ | ↑ | ↑ | ↔ |
|  | CCL22 | ↑ | ↑ | ↑ | ↔ |
|  | F7 | ↑ | ↑ | ↑ | ↔ |
|  | vWF | ↑ | ↑ | ↑ | ↑ |
|  | IL18 | ↓ | ↓ | ↑ | ↑ |
|  | VEGF | NR | NR | ↑ | ↑ |
|  | CSF1 | ↑ | ↔ | ↑ | ↑ |
|  | CCL11 | ↑ | ↔ | ↑ | ↑ |
|  | CCL5 | NR | NR | ↑ | ↑ |
|  | CCL9 | ↑ | ↔ | ↑ | ↑ |
|  | CD40L | NR | NR | ↑ | ↑ |
|  | CCL4 | ↑ | ↔ | ↑ | ↑ |
|  | XCL1 | NR | NR | ↑ | ↑ |
|  | CXCL5 | ↑ | ↑ ↔ | ↑ | ↑ |
|  | CCL3 | NR | NR | ↑ | ↑ |
|  | F3 | NR | NR | ↑ | ↑ ↔ |
|  | FGF2 | NR | NR | ↑ | ↑ |
|  | EDN1 | NR | NR | ↑ | ↑ |
|  | APCS | NR | NR | ↑ | ↑ |
|  | FGA | ↑ | ↔ | ↑ | ↑ |
|  | THPO | ↑ | ↑ ↔ | ↑ | ↑ |