Figure 1From: Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase BEnoxaparin and Akt deficient mice reduced hyperoxia-augmented lung stretch-induced microvascular leak and lung edema. Evans blue dye (EBD) analysis of lung tissue (A) and lung water measured by lung wet-to-dry-weight ratio (B) were from control, nonventilated mice and mice ventilated at tidal volume (VT) 30 ml/kg (VT 30 ml) for 8 hours with room air or hyperoxia. Enoxaparin, 4 mg/kg, was given subcutaneously 30 minutes before ventilation (n = 5 per group). * P < 0.05 versus control, nonventilated mice; †P < 0.05 versus all other groups. Akt+/- = serine/threonine kinase/protein kinase (Akt) deficient mice; LMWH = enoxaparin; RA = mice with room air.Back to article page