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Table 6 Multivariate analysis for the association with SNPs of CHRNA3/5 and nicotine dependence and emphysema severity in current smokers and ex-smokers

From: Epidemiology, radiology, and genetics of nicotine dependence in COPD

SNP (Chr. 15)

CHRNA3/5

    

rs8034191

rs1051730

FTND score*

Beta

SE

p

Beta

SE

p

Current smokers

Combined (312)

0.45

0.21

0.03

0.53

0.21

0.01

 

COPD (146)

0.32

0.30

0.30

0.29

0.31

0.35

 

Control(166)

0.51

0.28

0.07

0.66

0.28

0.02

Log (%emphysema)

 

Current smokers

Combined (312)

0.02

0.10

0.83

0.03

0.10

0.77

   

COPD (146)

-0.005

0.15

0.98

0.01

0.15

0.93

   

Control (166)

0.06

0.10

0.58

0.03

0.11

0.76

Ex-smokers

Combined (681)

0.14

0.07

0.047

0.14

0.07

0.049

   

COPD (344)

0.14

0.08

0.06

0.13

0.08

0.10

   

Control (337)

-0.03

0.07

0.68

-0.02

0.07

0.75

Current and ex-smokers

Combined (985)

0.11

0.06

0.06

0.12

0.06

0.05

   

COPD (490)

0.14

0.07

0.06

0.14

0.07

0.07

   

Control (495)

-0.001

0.06

0.99

-0.002

0.06

0.98

  1. * Adjusted for age and gender
  2. Adjusted for age, gender, BMI, and CT scanner; current smokers included only the subjects with available FTND scores.