Table 5 The association with SNPs of CHRNA3/5 and nicotine dependence, lung function, and emphysema severity in current smokers
From: Epidemiology, radiology, and genetics of nicotine dependence in COPD
SNP (Chr. 15) | rs8034191 | rs1051730 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Genotype (Number of subjects) | TT(126) | TC(145) | CC(38) | p | GG(129) | GA(137) | AA(36) | p | |
COPD affection | 49(38.9) | 78(53.8) | 17(44.7) | 0.13 | 50(38.8) | 72(52.6) | 16(44.4) | 0.14 | |
FTND score | Combined (312) | 4.5 ± 2.4 | 5.0 ± 2.6 | 5.1 ± 2.6 | 0.12 | 4.5 ± 2.4 | 5.1 ± 2.7 | 5.3 ± 2.6 | 0.03 |
COPD (146) | 4.8 ± 2.2 | 5.1 ± 2.6 | 5.4 ± 2.2 | 0.35 | 4.7 ± 2.2 | 5.3 ± 2.6 | 5.1 ± 2.1 | 0.27 | |
Control (166) | 4.3 ± 2.5 | 4.9 ± 2.7 | 4.8 ± 3.0 | 0.29 | 4.3 ± 2.5 | 4.8 ± 2.8 | 5.5 ± 2.9 | 0.08 | |
Pack-years of smoking | Combined | 46.2 ± 28.2 | 49.5 ± 24.2 | 47.1 ± 25.9 | 0.56 | 45.9 ± 27.8 | 49.7 ± 25.2 | 47.2 ± 24.6 | 0.46 |
COPD | 60.0 ± 36.5 | 55.8 ± 27.2 | 47.4 ± 26.3 | 0.16 | 59.3 ± 36.3 | 56.8 ± 28.7 | 45.4 ± 22.3 | 0.18 | |
Control | 37.4 ± 16.1 | 42.1 ± 17.8 | 46.8 ± 26.2 | 0.02 | 37.4 ± 16.0 | 41.8 ± 17.8 | 48.7 ± 26.7 | 0.01 | |
FEV1%pred | Combined | 80.4 ± 25.0 | 72.1 ± 26.6 | 78.2 ± 24.5 | 0.14 | 80.2 ± 25.2 | 74.4 ± 25.5 | 77.6 ± 25.0 | 0.21 |
COPD | 54.1 ± 16.8 | 51.8 ± 18.4 | 56.4 ± 16.3 | 0.96 | 53.6 ± 16.9 | 54.6 ± 17.6 | 55.4 ± 17.7 | 0.69 | |
Control | 97.1 ± 11.0 | 95.8 ± 9.9 | 95.9 ± 12.9 | 0.49 | 97.0 ± 10.9 | 96.4 ± 10.0 | 95.3 ± 12.7 | 0.50 | |
Log(%emphysema) | Combined | 4.7 ± 1.4 | 5.0 ± 1.3 | 4.6 ± 1.4 | 0.57 | 4.7 ± 1.4 | 4.9 ± 1.2 | 4.7 ± 1.5 | 0.60 |
COPD | 5.5 ± 1.2 | 5.6 ± 1.2 | 5.5 ± 1.4 | 0.87 | 5.6 ± 1.2 | 5.5 ± 1.2 | 5.8 ± 1.2 | 0.82 | |
Control | 4.2 ± 1.2 | 4.3 ± 1.0 | 4.0 ± 1.0 | 0.78 | 4.2 ± 1.2 | 4.3 ± 1.0 | 3.9 ± 0.9 | 0.61 | |