Figure 3

TBC3711 reduced a right ventricular hypertrophy and improved a right-heart function in monocrotaline model of pulmonary hypertension. Tricuspid annular plane systolic excursion (TAPSE) was measured by echocardiography. The right ventricle (RV) wall was separated from the left ventricle (LV) wall and ventricular septum (S). RV hypertrophy (heart ratio) was expressed as the weight ratio of the RV wall and free LV wall with ventricular septum (RV/(LV+S)) in different experimental groups. Additionally, right ventricular wall thickness (RVWT) and right ventricular dimensions (RVD) were measured by echocardiography. (a) TAPSE, (b) RV/(LV+S), (c) RVWT measured by echocardiography (RVWT-echo), (d) RVWT measured by invasive approach (RVWT invasive) and (e) RVD measured by echocardiography are shown for all experimental groups. Bars represent mean ± SEM. One-way ANOVA with Newman-Keuls multiple comparison post-hoc test was performed for statistical analysis. ***P < 0.001.