Physiologic and molecular consequences of endothelial Bmpr2 mutation

Respiratory Research

Table 1 Endothelial markers are not consistently changed by Bmpr2 mutation.

	Control		Delx4		R899X		ANOVA	Post Hoc (p < .05)	Control
CD34	7135	0.5%	10325	5.3%	8001	0.1%	<.01	Delx4 > Control	7135
Endoglin	2191	7.5%	5572	2.9%	316	4.6%	<.0001	Delx4 > Control > R899X	2191
Endothelial-Specific Marker 1	103	4.8%	119	1.8%	122	0.3%	<.05	Delx4 = R899X > Control	103
Flk1 (VEGF receptor 2)	1928	0.8%	1711	10.3%	684	3.6%	<.01	Delx4 = Control > R899X	1928
Flt1 (VEGF receptor 1)	484	4.6%	312	5.4%	370	0.8%	<.01	Control > R899X > Delx4	484
Icam2	190	3.3%	276	0.7%	201	0.4%	<.001	Delx4 > Control = R899X	190
Multimerin 2	118	10.9%	127	0.4%	113	6.4%	NS		118
Pecam1	114	14.6%	520	10.8%	118	3.3%	<.01	Delx > Control = R899X	114
Selectin, endothelial cell	156	4.7%	167	10.2%	174	8.5%	NS		156
Thrombomodulin	4855	3.5%	4669	3.9%	3013	6.8%	<.01	Delx4 = Control > R899X	4855
Vcam1	2264	3.6%	8066	1.7%	3483	0.2%	<.0001	Delx4 > R899X > Control	2264
VE-Cadherin	172	5.4%	230	0.1%	144	13.2%	<.05	Delx4 > Control = R899X	172
Vegf-a	1308	4.1%	1176	6.1%	2283	11.7%	<.05	R899X > Control = Delx4	1308
Von Willebrand factor	206	12.1%	231	5.5%	232	1.0%	NS		206

Numbers are the average of two raw Affymetrix hybridization intensity numbers for each condition, with the standard deviation given as a percentage of that number. ANOVA was performed for significant differences between groups, followed by a post-hoc t-test for which groups were different.

ISSN: 1465-993X