Figure 3
From: Physiologic and molecular consequences of endothelial Bmpr2 mutation
Increased inflammation in Tie2-Bmpr2delx4+ mouse lung compared to Tie2-rtTA only. Blue is DAPI nuclear stain; red corresponds to pan-leukocyte marker CD45 (A,B), macrophage marker CD68 (C,D), or T-cell marker CD3 (E,F). In all cases, there are substantially more inflammatory cells in representative fields from Tie2-Bmpr2delx4+ mouse lung than from control Tie2-rtTA only mouse lung. In contrast to this pattern, end-stage human lung is characterized by massive perivascular inflammation (G) which can be seen in Tie2-Bmpr2delx4+ mice (Additional Figure 1), but is not typical. Human lungs were prepared with Carstairs' Stain.