Figure 1
From: Physiologic and molecular consequences of endothelial Bmpr2 mutation
RVSP and muscularization are increased in Tie2- Bmpr2delx4+ mice. (A) Scatter plot showing RV systolic pressures from 11 Tie2- Bmpr2delx4+ mice and 6 control mice after 12 weeks' doxycycline. (B) Graph of muscularization of vessels visualized by actin staining showing a statistically significant increase in vessels under 25 μm compared to control at all time points, and an increase in muscularized vessels 25-50 μm compared to controls at the 8 and 12 week time points (p < .0001 by ANOVA with post-hoc t-test). There is never a statistically significant increase in muscularization in vessels over 50 μm. (C-F) Representative actin staining in control (C), 2.5 week (D), 8 week (E), and 12 week (F) time points, showing a progressive increase in small muscularized vessels.