TY - JOUR AU - Goodman, D. J. AU - Harrison, D. C. AU - Popp, R. L. PY - 1974 DA - 1974// TI - Echocardiographic features of primary pulmonary hypertension JO - Am J Cardiol VL - 33 UR - https://doi.org/10.1016/0002-9149(74)90329-4 DO - 10.1016/0002-9149(74)90329-4 ID - Goodman1974 ER - TY - JOUR AU - Stewart, D. J. PY - 1994 DA - 1994// TI - Endothelial dysfunction in pulmonary vascular disorders JO - Arzneimittelforschung VL - 44 ID - Stewart1994 ER - TY - JOUR AU - Sakao, S. AU - Tatsumi, K. PY - 2011 DA - 2011// TI - Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities JO - Int J Cardiol VL - 147 UR - https://doi.org/10.1016/j.ijcard.2010.07.003 DO - 10.1016/j.ijcard.2010.07.003 ID - Sakao2011 ER - TY - JOUR AU - Yang, X. AU - Long, L. AU - Reynolds, P. AU - Morrell, N. PY - 2011 DA - 2011// TI - Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells JO - Pulmonary Circulation VL - 1 UR - https://doi.org/10.4103/2045-8932.78100 DO - 10.4103/2045-8932.78100 ID - Yang2011 ER - TY - JOUR AU - Lane, K. B. AU - Machado, R. D. AU - Pauciulo, M. W. AU - Thomson, J. R. AU - Phillips, J. A. AU - Loyd, J. E. AU - Nichols, W. C. AU - Trembath, R. C. PY - 2000 DA - 2000// TI - Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium JO - Nat Genet VL - 26 UR - https://doi.org/10.1038/79226 DO - 10.1038/79226 ID - Lane2000 ER - TY - JOUR AU - Machado, R. D. AU - Pauciulo, M. W. AU - Thomson, J. R. AU - Lane, K. B. AU - Morgan, N. V. AU - Wheeler, L. AU - Phillips, J. A. r. AU - Newman, J. AU - Williams, D. AU - Galie, N. AU - Manes, A. AU - McNeil, K. AU - Yacoub, M. AU - Mikhail, G. AU - Rogers, P. AU - Corris, P. AU - Humbert, M. AU - Donnai, D. AU - Martensson, G. AU - Tranebjaerg, L. AU - Loyd, J. E. AU - Trembath, R. C. AU - Nichols, W. C. PY - 2001 DA - 2001// TI - BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension JO - Am J Hum Genet VL - 68 UR - https://doi.org/10.1086/316947 DO - 10.1086/316947 ID - Machado2001 ER - TY - JOUR AU - Rajkumar, R. AU - Konishi, K. AU - Richards, T. J. AU - Ishizawar, D. C. AU - Wiechert, A. C. AU - Kaminski, N. AU - Ahmad, F. PY - 2010 DA - 2010// TI - Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension JO - Am J Physiol Heart Circ Physiol VL - 298 UR - https://doi.org/10.1152/ajpheart.00254.2009 DO - 10.1152/ajpheart.00254.2009 ID - Rajkumar2010 ER - TY - JOUR AU - West, J. PY - 2010 DA - 2010// TI - Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension JO - Adv Exp Med Biol VL - 661 UR - https://doi.org/10.1007/978-1-60761-500-2_17 DO - 10.1007/978-1-60761-500-2_17 ID - West2010 ER - TY - JOUR AU - West, J. AU - Harral, J. AU - Lane, K. AU - Deng, Y. AU - Ickes, B. AU - Crona, D. AU - Albu, S. AU - Stewart, D. AU - Fagan, K. PY - 2008 DA - 2008// TI - Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions JO - Am J Physiol Lung Cell Mol Physiol VL - 295 UR - https://doi.org/10.1152/ajplung.90255.2008 DO - 10.1152/ajplung.90255.2008 ID - West2008 ER - TY - JOUR AU - Foletta, V. C. AU - Lim, M. A. AU - Soosairajah, J. AU - Kelly, A. P. AU - Stanley, E. G. AU - Shannon, M. AU - He, W. AU - Das, S. AU - Massague, J. AU - Bernard, O. PY - 2003 DA - 2003// TI - Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 JO - J Cell Biol VL - 162 UR - https://doi.org/10.1083/jcb.200212060 DO - 10.1083/jcb.200212060 ID - Foletta2003 ER - TY - JOUR AU - Wong, W. K. AU - Knowles, J. A. AU - Morse, J. H. PY - 2005 DA - 2005// TI - Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension JO - Am J Respir Cell Mol Biol VL - 33 UR - https://doi.org/10.1165/rcmb.2005-0103OC DO - 10.1165/rcmb.2005-0103OC ID - Wong2005 ER - TY - JOUR AU - Rudarakanchana, N. AU - Flanagan, J. A. AU - Chen, H. AU - Upton, P. D. AU - Machado, R. AU - Patel, D. AU - Trembath, R. C. AU - Morrell, N. W. PY - 2002 DA - 2002// TI - Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension JO - Hum Mol Genet VL - 11 UR - https://doi.org/10.1093/hmg/11.13.1517 DO - 10.1093/hmg/11.13.1517 ID - Rudarakanchana2002 ER - TY - JOUR AU - Tada, Y. AU - Majka, S. AU - Carr, M. AU - Harral, J. AU - Crona, D. AU - Kuriyama, T. AU - West, J. PY - 2007 DA - 2007// TI - Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH JO - Am J Physiol Lung Cell Mol Physiol VL - 292 UR - https://doi.org/10.1152/ajplung.00305.2006 DO - 10.1152/ajplung.00305.2006 ID - Tada2007 ER - TY - JOUR AU - West, J. AU - Fagan, K. AU - Steudel, W. AU - Fouty, B. AU - Lane, K. AU - Harral, J. AU - Hoedt-Miller, M. AU - Tada, Y. AU - Ozimek, J. AU - Tuder, R. AU - Rodman, D. M. PY - 2004 DA - 2004// TI - Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle JO - Circ Res VL - 94 UR - https://doi.org/10.1161/01.RES.0000126047.82846.20 DO - 10.1161/01.RES.0000126047.82846.20 ID - West2004 ER - TY - JOUR AU - Yelle, D. AU - Deng, Y. P. AU - West, J. AU - Stewart, D. J. PY - 2009 DA - 2009// TI - Endothelial-Targeted BMPR2 Loss-of-Function Mutations Cause Increased Apoptosis and Pulmonary Arterial Hypertension JO - Circulation VL - 120 UR - https://doi.org/10.1161/CIRCULATIONAHA.109.192601 DO - 10.1161/CIRCULATIONAHA.109.192601 ID - Yelle2009 ER - TY - JOUR AU - Wall, D. S. AU - Gendron, R. L. AU - Good, W. V. AU - Miskiewicz, E. AU - Woodland, M. AU - Leblanc, K. AU - Paradis, H. PY - 2004 DA - 2004// TI - Conditional knockdown of tubedown-1 in endothelial cells leads to neovascular retinopathy JO - Invest Ophthalmol Vis Sci VL - 45 UR - https://doi.org/10.1167/iovs.03-1410 DO - 10.1167/iovs.03-1410 ID - Wall2004 ER - TY - JOUR AU - Paradis, H. AU - Islam, T. AU - Tucker, S. AU - Tao, L. AU - Koubi, S. AU - Gendron, R. L. PY - 2008 DA - 2008// TI - Tubedown associates with cortactin and controls permeability of retinal endothelial cells to albumin JO - J Cell Sci VL - 121 UR - https://doi.org/10.1242/jcs.028597 DO - 10.1242/jcs.028597 ID - Paradis2008 ER - TY - CHAP AU - Gendron, R. L. AU - Laver, N. V. AU - Good, W. V. AU - Grossniklaus, H. E. AU - Miskiewicz, E. AU - Whelan, M. A. AU - Walker, J. AU - Paradis, H. PY - 2010 DA - 2010// TI - Loss of Tubedown Expression as a contributing factor in the Development of Age-Related Retinopathy BT - Invest Ophthalmol Vis Sci ID - Gendron2010 ER - TY - JOUR AU - Carstairs, K. C. PY - 1965 DA - 1965// TI - The identification of platelets and platelet antigens in histological sections JO - J Pathol Bacteriol VL - 90 UR - https://doi.org/10.1002/path.1700900124 DO - 10.1002/path.1700900124 ID - Carstairs1965 ER - TY - JOUR AU - Jat, P. S. AU - Noble, M. D. AU - Ataliotis, P. AU - Tanaka, Y. AU - Yannoutsos, N. AU - Larsen, L. AU - Kioussis, D. PY - 1991 DA - 1991// TI - Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse JO - Proc Natl Acad Sci USA VL - 88 UR - https://doi.org/10.1073/pnas.88.12.5096 DO - 10.1073/pnas.88.12.5096 ID - Jat1991 ER - TY - JOUR AU - Pozzi, A. AU - Moberg, P. E. AU - Miles, L. A. AU - Wagner, S. AU - Soloway, P. AU - Gardner, H. A. PY - 2000 DA - 2000// TI - Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization JO - Proc Natl Acad Sci USA VL - 97 UR - https://doi.org/10.1073/pnas.040378497 DO - 10.1073/pnas.040378497 ID - Pozzi2000 ER - TY - JOUR AU - Zhang, B. AU - Kirov, S. AU - Snoddy, J. PY - 2005 DA - 2005// TI - WebGestalt: an integrated system for exploring gene sets in various biological contexts JO - Nucleic Acids Res VL - 33 UR - https://doi.org/10.1093/nar/gki475 DO - 10.1093/nar/gki475 ID - Zhang2005 ER - TY - JOUR AU - Herve, P. AU - Humbert, M. AU - Sitbon, O. AU - Parent, F. AU - Nunes, H. AU - Legal, C. AU - Garcia, G. AU - Simonneau, G. PY - 2001 DA - 2001// TI - Pathobiology of pulmonary hypertension. The role of platelets and thrombosis JO - Clin Chest Med VL - 22 UR - https://doi.org/10.1016/S0272-5231(05)70283-5 DO - 10.1016/S0272-5231(05)70283-5 ID - Herve2001 ER - TY - JOUR AU - Wagenvoort, C. A. PY - 1995 DA - 1995// TI - Pathology of pulmonary thromboembolism JO - Chest VL - 107 UR - https://doi.org/10.1378/chest.107.1_Supplement.10S DO - 10.1378/chest.107.1_Supplement.10S ID - Wagenvoort1995 ER - TY - JOUR AU - Wagenvoort, C. A. AU - Mulder, P. G. PY - 1993 DA - 1993// TI - Thrombotic lesions in primary plexogenic arteriopathy. Similar pathogenesis or complication? JO - Chest VL - 103 UR - https://doi.org/10.1378/chest.103.3.844 DO - 10.1378/chest.103.3.844 ID - Wagenvoort1993 ER - TY - JOUR AU - Teichert-Kuliszewska, K. AU - Kutryk, M. J. AU - Kuliszewski, M. A. AU - Karoubi, G. AU - Courtman, D. W. AU - Zucco, L. AU - Granton, J. AU - Stewart, D. J. PY - 2006 DA - 2006// TI - Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension JO - Circ Res VL - 98 UR - https://doi.org/10.1161/01.RES.0000200180.01710.e6 DO - 10.1161/01.RES.0000200180.01710.e6 ID - Teichert-Kuliszewska2006 ER - TY - JOUR AU - Lane, K. AU - Talati, M. AU - Austin, E. AU - Hemnes, A. AU - Johnson, J. AU - Fessel, J. AU - Blackwell, T. AU - Mernaugh, R. AU - Robinson, L. AU - Fike, C. AU - Roberts Ii, L. AU - West, J. PY - 2011 DA - 2011// TI - Oxidative injury is a common consequence of BMPR2 mutations JO - Pulmonary Circulation VL - 1 UR - https://doi.org/10.4103/2045-8932.78107 DO - 10.4103/2045-8932.78107 ID - Lane2011 ER - TY - JOUR AU - Park, K. AU - Kim, K. AU - Rho, S. B. AU - Choi, K. AU - Kim, D. AU - Oh, S. H. AU - Park, J. AU - Lee, S. H. AU - Lee, J. H. PY - 2005 DA - 2005// TI - Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis JO - Cancer Res VL - 65 ID - Park2005 ER - TY - JOUR AU - Kiyono, M. AU - Shibuya, M. PY - 2003 DA - 2003// TI - Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression JO - Mol Cell Biol VL - 23 UR - https://doi.org/10.1128/MCB.23.13.4627-4636.2003 DO - 10.1128/MCB.23.13.4627-4636.2003 ID - Kiyono2003 ER - TY - JOUR AU - Bendall, A. J. AU - Rincon-Limas, D. E. AU - Botas, J. AU - Abate-Shen, C. PY - 1998 DA - 1998// TI - Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity JO - Differentiation VL - 63 UR - https://doi.org/10.1046/j.1432-0436.1998.6330151.x DO - 10.1046/j.1432-0436.1998.6330151.x ID - Bendall1998 ER - TY - CHAP AU - Jurasz, P. AU - Yurkova, N. AU - Kirshenbaum, L. AU - Stewart, D. J. PY - 2011 DA - 2011// TI - VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells BT - Angiogenesis ID - Jurasz2011 ER - TY - JOUR AU - Doumont, G. AU - Martoriati, A. AU - Marine, J. C. PY - 2005 DA - 2005// TI - PTPRV is a key mediator of p53-induced cell cycle exit JO - Cell Cycle VL - 4 UR - https://doi.org/10.4161/cc.4.12.2207 DO - 10.4161/cc.4.12.2207 ID - Doumont2005 ER - TY - JOUR AU - Toumaniantz, G. AU - Ferland-McCollough, D. AU - Cario-Toumaniantz, C. AU - Pacaud, P. AU - Loirand, G. PY - 2010 DA - 2010// TI - The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration JO - Cardiovasc Res VL - 86 UR - https://doi.org/10.1093/cvr/cvp387 DO - 10.1093/cvr/cvp387 ID - Toumaniantz2010 ER - TY - JOUR AU - Zitzler, J. AU - Link, D. AU - Schafer, R. AU - Liebetrau, W. AU - Kazinski, M. AU - Bonin-Debs, A. AU - Behl, C. AU - Buckel, P. AU - Brinkmann, U. PY - 2004 DA - 2004// TI - High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide JO - Mol Cell Proteomics VL - 3 UR - https://doi.org/10.1074/mcp.M400054-MCP200 DO - 10.1074/mcp.M400054-MCP200 ID - Zitzler2004 ER - TY - JOUR AU - Yeh, C. S. AU - Wang, J. Y. AU - Chung, F. Y. AU - Lee, S. C. AU - Huang, M. Y. AU - Kuo, C. W. AU - Yang, M. J. AU - Lin, S. R. PY - 2008 DA - 2008// TI - Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers JO - Oncol Rep VL - 19 ID - Yeh2008 ER - TY - JOUR AU - Cohen, R. AU - Holland, J. P. AU - Yokoi, T. AU - Holland, M. J. PY - 1986 DA - 1986// TI - Identification of a regulatory region that mediates glucose-dependent induction of the Saccharomyces cerevisiae enolase gene ENO2 JO - Mol Cell Biol VL - 6 UR - https://doi.org/10.1128/MCB.6.7.2287 DO - 10.1128/MCB.6.7.2287 ID - Cohen1986 ER - TY - JOUR AU - Timmers, S. AU - Schrauwen, P. AU - de Vogel, J. PY - 2008 DA - 2008// TI - Muscular diacylglycerol metabolism and insulin resistance JO - Physiol Behav VL - 94 UR - https://doi.org/10.1016/j.physbeh.2007.12.002 DO - 10.1016/j.physbeh.2007.12.002 ID - Timmers2008 ER - TY - JOUR AU - Liekens, S. AU - Schols, D. AU - Hatse, S. PY - 2010 DA - 2010// TI - CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization JO - Curr Pharm Des VL - 16 UR - https://doi.org/10.2174/138161210794455003 DO - 10.2174/138161210794455003 ID - Liekens2010 ER - TY - JOUR AU - Jackson, S. W. AU - Hoshi, T. AU - Wu, Y. AU - Sun, X. AU - Enjyoji, K. AU - Cszimadia, E. AU - Sundberg, C. AU - Robson, S. C. PY - 2007 DA - 2007// TI - Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice JO - Am J Pathol VL - 171 UR - https://doi.org/10.2353/ajpath.2007.070190 DO - 10.2353/ajpath.2007.070190 ID - Jackson2007 ER - TY - CHAP AU - Burton, V. J. AU - Ciuclan, L. I. AU - Holmes, A. M. AU - Rodman, D. M. AU - Walker, C. AU - Budd, D. C. PY - 2010 DA - 2010// TI - Bone morphogenetic protein receptor-II regulates pulmonary artery endothelial cell barrier function BT - Blood ID - Burton2010 ER - TY - JOUR AU - Hong, K. H. AU - Lee, Y. J. AU - Lee, E. AU - Park, S. O. AU - Han, C. AU - Beppu, H. AU - Li, E. AU - Raizada, M. K. AU - Bloch, K. D. AU - Oh, S. P. PY - 2008 DA - 2008// TI - Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension JO - Circulation VL - 118 UR - https://doi.org/10.1161/CIRCULATIONAHA.107.736801 DO - 10.1161/CIRCULATIONAHA.107.736801 ID - Hong2008 ER - TY - JOUR AU - Wagenvoort, C. A. PY - 1960 DA - 1960// TI - Vasoconstriction and medial hypertrophy in pulmonary hypertension JO - Circulation VL - 22 UR - https://doi.org/10.1161/01.CIR.22.4.535 DO - 10.1161/01.CIR.22.4.535 ID - Wagenvoort1960 ER - TY - JOUR AU - Stenmark, K. R. AU - Meyrick, B. AU - Galie, N. AU - Mooi, W. J. AU - McMurtry, I. F. PY - 2009 DA - 2009// TI - Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure JO - Am J Physiol Lung Cell Mol Physiol VL - 297 UR - https://doi.org/10.1152/ajplung.00217.2009 DO - 10.1152/ajplung.00217.2009 ID - Stenmark2009 ER -