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Figure 5 | Respiratory Research

Figure 5

From: Ultrastructural changes of the intracellular surfactant pool in a rat model of lung transplantation-related events

Figure 5

Comparison of the luminal surface area of AE2 cells (S(lumen, AE2)) and the assumption-based calculated total surface area of the limiting membrane of Lb per AE2 cell (S(LB, AE2)) between the control group and the I/R group. Whereas the total surface of the limiting membrane was higher than the luminal surface area per AE2 cell in the control group, it was the other way round in the I/R group. The mean sum of S(lumen, AE2) and S(LB, AE2) within the control group was 353 μm2 (95% CI 326-380 μm2) which was comparable to the mean sum of S(lumen, AE2) and S(LB, AE2) in the I/R group of 368 μm2 (95% CI 308-428 μm2). This fact indicates that there was a shift of the limiting membrane to the luminal surface area due to exocytosis of Lb. Level of significance: control S(Lb, AE2) vs. I/R S(Lb, AE2) p = 0.02; control S(lumen, AE2) vs. I/R S(lumen, AE2) p = 0.02.

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