Figure 8

P38 MAPK inhibitor suppresses senescence-associated airway inflammation in mice. (A) Representative photomicrographs of double immunofluorescence staining for phospho-p38 MAPK (green) and CC10 (red) in the distal airway. Arrows indicate CC10-positive Clara cells that express phospho-p38 MAPK in their nuclei. Treatment with SB202190 of mice repeatedly exposed to NA and injected with BrdU reduces the proportion of Clara cells that express phospho-p38 MAPK (B) and the numbers of CD45-positive cells and CD90.2-positive cells infiltrating the distal airways (C) but does not affect the number of Clara cells (D) or the number of Clara cells that express p21 (E). Data are expressed as the means ± SEM. N = 4-6 in each experiment.