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Table 2 The association of IL8 SNPs with the risk of idiopathic pulmonary fibrosis (IPF)

From: A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

rs

s

Distribution

Codominant

Dominant

Recessive

MAF

Statistical power

  

Case

NC

OR(95%CI)

P

Pcorr

OR(95%CI)

P

Pcorr

OR(95%CI)

P

Pcorr

Case

NC

 

rs4073

T

87(41.63%)

191(42.16%)

            
 

AT

103(49.28%)

191(42.16%)

0.84(0.65-1.08)

0.17

0.22

1.00(0.71

-1.42)

0.99

1

0.46(0.26-

0.80)

0.006

0.008

0.337

0.368

82.2%

 

A

19(9.09%)

71(15.67%)

            

rs2227307

T

94(42.34%)

191(42.35%)

            
 

GT

107(48.20%)

189(41.91%)

0.83(0.65-1.06)

0.14

0.19

0.97(0.69

-1.37)

0.87

1

0.48(0.28-

0.82)

0.007

0.009

0.336

0.367

93.5%

 

G

21(9.46%)

71(15.74%)

            

rs2227306

C

103(48.13%)

216(47.58%)

            
 

CT

95(44.39%)

196(43.17%)

0.92(0.70-1.19)

0.51

0.67

0.97(0.69

-1.36)

0.84

1

0.70(0.37-

1.30)

0.26

0.34

0.297

0.308

79.9%

 

T

16(7.48%)

42(9.25%)

            

IL8_ht3

-/-

175(91.15%)

398(87.86%)

            
 

ht3/-

16(8.33%)

55(12.14%)

0.65(0.37-1.16)

0.15

0.19

0.61(0.34

-1.10)

0.10

0.13

.

.

.

0.047

0.061

35.6%

 

ht3/ht3

1(0.52%)

0(0.00%)

            
  1. * Logistic models were used for calculating odd ration and p-values in recessive model controlling for age, sex, and smoking status as covariates.
  2. NC: normal controls
  3. MAF: Minor allele frequency
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Respiratory Research

ISSN: 1465-993X

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