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Table 2 The association of IL8 SNPs with the risk of idiopathic pulmonary fibrosis (IPF)

From: A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

rs s Distribution Codominant Dominant Recessive MAF Statistical power
   Case NC OR(95%CI) P Pcorr OR(95%CI) P Pcorr OR(95%CI) P Pcorr Case NC  
rs4073 T 87(41.63%) 191(42.16%)             
  AT 103(49.28%) 191(42.16%) 0.84(0.65-1.08) 0.17 0.22 1.00(0.71 -1.42) 0.99 1 0.46(0.26- 0.80) 0.006 0.008 0.337 0.368 82.2%
  A 19(9.09%) 71(15.67%)             
rs2227307 T 94(42.34%) 191(42.35%)             
  GT 107(48.20%) 189(41.91%) 0.83(0.65-1.06) 0.14 0.19 0.97(0.69 -1.37) 0.87 1 0.48(0.28- 0.82) 0.007 0.009 0.336 0.367 93.5%
  G 21(9.46%) 71(15.74%)             
rs2227306 C 103(48.13%) 216(47.58%)             
  CT 95(44.39%) 196(43.17%) 0.92(0.70-1.19) 0.51 0.67 0.97(0.69 -1.36) 0.84 1 0.70(0.37- 1.30) 0.26 0.34 0.297 0.308 79.9%
  T 16(7.48%) 42(9.25%)             
IL8_ht3 -/- 175(91.15%) 398(87.86%)             
  ht3/- 16(8.33%) 55(12.14%) 0.65(0.37-1.16) 0.15 0.19 0.61(0.34 -1.10) 0.10 0.13 . . . 0.047 0.061 35.6%
  ht3/ht3 1(0.52%) 0(0.00%)             
  1. * Logistic models were used for calculating odd ration and p-values in recessive model controlling for age, sex, and smoking status as covariates.
  2. NC: normal controls
  3. MAF: Minor allele frequency