Figure 2From: Claudins in lung diseasesInteraction of claudins with scaffolding proteins ZO-1, ZO-2, ZO-3, MUPP1, cingulin and ZONAB in tight junctional structures. The arrows show interactions between specific molecules. If ZONAB is released from the association with ZO-1 it moves to the nucleus and binds to cyclin dependent kinase 4 (CDK 4) resulting in cellular proliferation. Apg-2 competes with ZONAB for the same binding site in ZO-1 thus affecting the binding of ZONAB to ZO-1 and releasing it to the nucleus. This is one example how tight junction proteins may influence the functions of the cellBack to article page