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Table 1 MDA levels, MPO activity and peroxynitrite levels in lung homogenates WT or AMPKα1 deficient mice

From: AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice

 

control mice

AMPKα1 deficient mice

 
 

Air

Ozone

Air

Ozone

 

MDA (μmol/g wet tissue)

110 +/- 14.1*

230 +/- 10*

160 +/- 13

147 +/- 12.6

*p < 0.0001

MPO (U/g wet tissue)

0.13 +/- 0.03*

0.27 +/- 0.04*

0.13 +/- 0.02

0.16 +/- 0.06

*p = 0.04

Peroxynitrite (nmol/L)

3.0 +/- 0.2*

4.4 +/- 1.0*

2.8 +/- 0.5

2.8 +/- 0.4

*p = 0.03

  1. Mice were exposed to air with or without ozone at 2 ppm for 3 h. Parameters were evaluated 24 h after exposure. Malondialdehyde (MDA) was expressed as micromole per g weight of wet tissue; Myeloperoxidase activity (MPO) was expressed in units per gram weight of wet tissue. Peroxynitrite was expressed as nmol/L. Data are presented as means ± SD. *: p < 0.05; μmol/g wet tissue: micromole per g weight of wet tissue; U/g wet tissue: units per gram weight of wet tissue