| control mice | AMPKα1 deficient mice | |
---|
| Air | Ozone | Air | Ozone | |
---|
MDA (μmol/g wet tissue) | 110 +/- 14.1* | 230 +/- 10* | 160 +/- 13 | 147 +/- 12.6 | *p < 0.0001 |
MPO (U/g wet tissue) | 0.13 +/- 0.03* | 0.27 +/- 0.04* | 0.13 +/- 0.02 | 0.16 +/- 0.06 | *p = 0.04 |
Peroxynitrite (nmol/L) | 3.0 +/- 0.2* | 4.4 +/- 1.0* | 2.8 +/- 0.5 | 2.8 +/- 0.4 | *p = 0.03 |
- Mice were exposed to air with or without ozone at 2 ppm for 3 h. Parameters were evaluated 24 h after exposure. Malondialdehyde (MDA) was expressed as micromole per g weight of wet tissue; Myeloperoxidase activity (MPO) was expressed in units per gram weight of wet tissue. Peroxynitrite was expressed as nmol/L. Data are presented as means ± SD. *: p < 0.05; μmol/g wet tissue: micromole per g weight of wet tissue; U/g wet tissue: units per gram weight of wet tissue