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Table 1 Differentially expressed network hubs in VSELs exposed to in vivo hypoxia

From: Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia

Node Name

Symbol

Connectivity

Q-value

FBJ osteosarcoma oncogene

Fos

42

1.9 × 10-2

Peroxisome proliferator activated receptor gamma

Pparγ

39

3.9 × 10-2

Epidermal growth factor receptor

Egfr

28

5.3 × 10-4

Early growth response 1

Egr1

19

6.9 × 10-3

Early growth response 2

Egr2

19

2.8 × 10-2

Integrin beta 3

Itgb3

18

3.3 × 10-3

TATA box binding protein

Tbp

15

2.2 × 10-2

Hypoxia-inducible factor 2 alpha

Hif2α

15

1.7 × 10-2

Collagen type I alpha 1

Col1a1

15

2.5 × 10-2

Heat shock protein 8

Hspa8

14

4.1 × 10-2

Insulin receptor substrate 1

Irs1

13

8.9 × 10-5

Insulin-like growth factor binding protein 5

Igfbp5

12

5.7 × 10-7

Heat shock protein 5

Hspa5

11

2.5 × 10-2

Disrupted in schizophrenia 1

Disc1

11

8.1 × 10-3

Homeobox A9

Hoxa9

11

1.8 × 10-2

Von Willebrand factor homolog

Vwf

11

9.1 × 10-3

Peroxisome proliferative activated receptor gamma coactivator 1 alpha

Ppargc1a

10

2.1 × 10-4

Hypermethylated in cancer 1

Hic1

10

2.6 × 10-2