Figure 3
From: Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
Effects of inhibiting c-kit and MC degranulation on PH and right ventricular hypertrophy (RVH) of MCT-rats. Rats were treated with selective c-kit inhibitor (PLX), MC stabilizer (Cromolyn) or placebo from day 1 to 21 after MCT-injection. The rats in healthy group received saline injection instead of MCT. (A) Right ventricular systolic pressure (RVSP), (B) Right to left ventricular plus septum weight ratio (RV/(LV+S)) and (C) Systemic arterial pressure (SAP)are given. Each bar represents Mean ± SEM (n = 8-10). *p < 0.05 versus healthy; †p < 0.05 versus MCT-placebo.