Table 6 All-cause mortality in tiotropium and placebo groups according to different threshold criteria for bronchodilator responsiveness.
From: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial
Tiotropium | Placebo | Hazard Ratio (95% CI) (tiotropium/placebo) | p-value | |
|---|---|---|---|---|
Responsiveness Criterion A | ||||
Nonresponder (%) | 208/1357 (15.3) | 225/1393 (16.2) | 0.84 (0.70, 1.02) | 0.07 |
Responder (%) | 152/1520 (10.0) | 164/1513 (10.8) | 0.86 (0.69, 1.07) | 0.17 |
Responsiveness Criterion B | ||||
Nonresponder | 141/995 (14.2) | 151/1000 (15.1) | 0.87 (0.69, 1.10) | 0.24 |
Responder | 219/1882 (11.6) | 238/1906 (12.5) | 0.84 (0.70, 1.01) | 0.06 |
Responsiveness Criterion C | ||||
Nonresponder (%) | 265/1769 (15.0) | 283/1784 (15.9) | 0.85 (0.72, 1.00) | 0.05 |
Responder (%) | 95/1108 (8.6) | 106/1122 (9.4) | 0.84 (0.64, 1.11) | 0.22 |