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Table 6 All-cause mortality in tiotropium and placebo groups according to different threshold criteria for bronchodilator responsiveness.

From: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial

  Tiotropium Placebo Hazard Ratio (95% CI) (tiotropium/placebo) p-value
Responsiveness Criterion A     
   Nonresponder (%) 208/1357 (15.3) 225/1393 (16.2) 0.84 (0.70, 1.02) 0.07
   Responder (%) 152/1520 (10.0) 164/1513 (10.8) 0.86 (0.69, 1.07) 0.17
Responsiveness Criterion B     
   Nonresponder 141/995 (14.2) 151/1000 (15.1) 0.87 (0.69, 1.10) 0.24
   Responder 219/1882 (11.6) 238/1906 (12.5) 0.84 (0.70, 1.01) 0.06
Responsiveness Criterion C     
   Nonresponder (%) 265/1769 (15.0) 283/1784 (15.9) 0.85 (0.72, 1.00) 0.05
   Responder (%) 95/1108 (8.6) 106/1122 (9.4) 0.84 (0.64, 1.11) 0.22
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