From: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial
Tiotropium | Placebo | Hazard (or Rate) Ratio (95%CI) (tiotropium/placebo) | p-value | |
---|---|---|---|---|
Patients with ≥1 exacerbation, n (%) | ||||
Responsiveness Criterion A | ||||
Nonresponder | 913 (67.3) | 946 (67.9) | 0.86 (0.79, 0.94) | 0.0014 |
Responder | 1021 (67.2) | 1036 (68.5) | 0.86 (0.79, 0.94) | 0.0008 |
Responsiveness Criterion B | ||||
Nonresponder | 634 (63.7) | 676 (67.6) | 0.85 (0.76, 0.95) | 0.0029 |
Responder | 1300 (69.1) | 1306 (68.5) | 0.87 (0.80, 0.94) | 0.0003 |
Responsiveness Criterion C | ||||
Nonresponder | 1198 (67.7) | 1204 (67.5) | 0.89 (0.82, 0.96) | 0.0036 |
Responder | 736 (66.4) | 778 (69.3) | 0.82 (0.74, 0.91) | 0.0002 |
Number of exacerbations/patient year, mean | ||||
Responsiveness Criterion A | ||||
Nonresponder | 0.76 | 0.87 | 0.87 (0.79, 0.95) | 0.0019 |
Responder | 0.69 | 0.82 | 0.85 (0.78, 0.92) | 0.0002 |
Responsiveness Criterion B | ||||
Nonresponder | 0.65 | 0.77 | 0.84 (0.75, 0.94) | 0.0026 |
Responder | 0.76 | 0.88 | 0.86 (0.80, 0.93) | 0.0001 |
Responsiveness Criterion C | ||||
Nonresponder | 0.74 | 0.86 | 0.86 (0.79, 0.93) | 0.0001 |
Responder | 0.70 | 0.81 | 0.86 (0.77, 0.95) | 0.0025 |