Table 1 Baseline characteristics of tiotropium and placebo groups according to different threshold criteria for bronchodilator responsiveness.
From: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial
Criterion A (∆ % Predicted FEV1≥12% and ≥200 mL) | Criterion B (∆ % Predicted FEV1≥15%) | Criterion C (∆ % Predicted FEV1≥10%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nonresponder (n = 2750) | Responder (n = 3033) | Nonresponder (n = 1995) | Responder (n = 3788) | Nonresponder (n = 3553) | Responder (n = 2230) | |||||||
Tio (n = 1357) | Placebo (n = 1393) | Tio (n = 1520) | Placebo (n = 1513) | Tio (n = 995) | Placebo (n = 1000) | Tio (n = 1882) | Placebo (n = 1906) | Tio (n = 1769) | Placebo (n = 1784) | Tio (n = 1108) | Placebo(n = 1122) | |
Age (years) | 64.9 ± 8.4 | 65.3 ± 8.4 | 64.1 ± 8.4 | 63.8 ± 8.5 | 64.4 ± 8.3 | 64.5 ± 8.5 | 64.5 ± 8.5 | 64.5 ± 8.5 | 64.4 ± 8.3 | 64.6 ± 8.4 | 64.7 ± 8.6 | 64.3 ± 8.7 |
Male, % | 69.7 | 69.2 | 80.2 | 78.6 | 77.0 | 75.7 | 74.3 | 73.2 | 76.2 | 75.6 | 73.7 | 71.7 |
Smoking history (%) | ||||||||||||
Ex-smoker | 69.6 | 70.7 | 71.6 | 69.3 | 67.8 | 67.5 | 72.1 | 71.2 | 69.3 | 70.7 | 72.727.3 | 68.8 |
Current smoker | 30.4 | 29.3 | 28.4 | 30.7 | 32.2 | 32.5 | 27.9 | 28.8 | 30.7 | 29.3 | 31.2 | |
Mean COPD duration (years) | 10.1 ± 7.7 | 9.8 ± 7.7 | 9.7 ± 7.5 | 9.6 ± 7.0 | 9.9 ± 7.6 | 9.7 ± 7.5 | 9.9 ± 7.5 | 9.7 ± 7.3 | 10.1 ± 7.7 | 9.7 ± 7.5 | 9.6 ± 7.4 | 9.6 ± 7.1 |
Baseline medication* use (%) | ||||||||||||
LABA | 60.0 | 61.5 | 59.7 | 59.1 | 56.9 | 59.1 | 61.4 | 60.8 | 59.8 | 61.7 | 59.9 | 57.8 |
ICS | 62.1 | 62.5 | 60.8 | 60.7 | 58.9 | 59.9 | 62.8 | 62.4 | 61.6 | 61.7 | 61.2 | 61.4 |
Combination ICS+LABA | 49.2 | 50.0 | 48.4 | 47.3 | 45.2 | 47.6 | 50.6 | 49.1 | 48.5 | 49.7 | 49.1 | 46.7 |
Anticholinergic | 46.9 | 47.6 | 44.9 | 42.7 | 44.0 | 43.9 | 46.8 | 45.6 | 47.1 | 45.8 | 43.9 | 43.9 |
Theophyllines | 31.6 | 33.0 | 26.3 | 24.3 | 29.0 | 31.4 | 28.7 | 27.0 | 30.7 | 31.7 | 25.8 | 23.4 |
SGRQ total score (units) | 47.2 ± 17.2 | 48.0 ± 17.5 | 44.5 ± 16.7 | 43.9 ± 16.7 | 45.4 ± 17.5 | 46.6 ± 17.8 | 46.0 ± 16.7 | 45.5 ± 16.9 | 46.9 ± 17.2 | 47.1 ± 17.2 | 44.0 ± 16.6 | 43.9 ± 17.0 |